NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND DYSPEPSIA IN THE ELDERLY
NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND DYSPEPSIA IN THE ELDERLY
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DOI：
10.1007/bf02065549
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发表时间：
1995-06-01
影响因子：
3.1
通讯作者：
MELTON, LJ
中科院分区：
文献类型：
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作者：
TALLEY, NJ;EVANS, JM;MELTON, LJ
上消化道症状在老年人中很常见，尽管缺乏数据，但非甾体抗炎药（NSAIDs）被认为是重要的危险因素。我们的目的是在一项基于人群的研究中评估非甾体抗炎药与消化不良和胃灼热的关系。随机抽取明尼苏达州奥姆斯特德县65岁及以上白种人居民，按年龄和性别分层，邮寄一份有效的自我报告问卷；有74%的人回应（N = 1375）。计算非甾体抗炎药（NSAID）使用、消化不良（定义为上腹部疼痛或恶心）和胃灼热（定义为胸骨后烧灼痛）的年龄和性别调整患病率（至1980年美国高加索人群）。采用Logistic回归分析估计消化不良和胃灼热与调整年龄和性别的潜在危险因素的关系。经年龄和性别调整的阿司匹林和非阿司匹林类非甾体抗炎药使用的年患病率（每100人）分别为60.0 （95% CI 57.2,62.7）和26.1 （95% CI 23.6,28.7）。消化不良和胃灼热的年患病率分别为15.0 （95% CI 12.9,17.0）和12.9 （95% CI 10.9,14.8）。阿司匹林与消化不良和/或胃灼热相关（or = 1.6, 95% CI 1.2,2.2），非阿司匹林类非甾体抗炎药与消化不良和/或胃灼热相关（or = 1.8, 95% CI 1.3,2.6），但吸烟和酒精不是显著的危险因素。阿司匹林和非阿司匹林类非甾体抗炎药与老年社区受试者上胃肠道症状的风险几乎是两倍相关。
Upper gastrointestinal tract symptoms are common in the elderly and, despite a paucity of data, nonsteroidal antiinflammatory drugs (NSAIDs) are believed to be important risk factors. We aimed to evaluate the association of NSAIDs with dyspepsia and heartburn in a population-based study. An age- and gender-stratified random sample of Olmsted County, Minnesota, Caucasian residents aged 65 years and older was mailed a valid self-report questionnaire; 74% responded (N = 1375). Age- and gender-adjusted (to 1980 US Caucasian population) prevalence rates for NSAID use, dyspepsia (defined as pain located in the upper abdomen or nausea), and heartburn (defined as retrosternal burning pain) were calculated. Logistic regression analysis was used to estimate the association of dyspepsia and heartburn with potential risk factors adjusting for age and gender. The age- and gender-adjusted annual prevalences (per 100) of aspirin and nonaspirin NSAID use were 60.0 (95% CI 57.2,62.7) and 26.1 (95% CI 23.6,28.7), respectively. The annual prevalences of dyspepsia and heartburn were 15.0 (95% CI 12.9,17.0) and 12.9 (95% CI 10.9,14.8), respectively. Aspirin was associated with dyspepsia and/or heartburn (OR = 1.6, 95% CI 1.2,2.2) as were nonaspirin NSAIDs (OR = 1.8, 95% CI 1.3,2.6), but smoking and alcohol were not significant risk factors. Aspirin and nonaspirin NSAIDs are associated with almost a twofold risk of upper gastrointestinal tract symptoms in elderly community subjects.