Cerebral perfusion changes during cataplexy in narcolepsy patients
Cerebral perfusion changes during cataplexy in narcolepsy patients
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DOI：
10.1212/01.wnl.0000218205.72668.ab
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发表时间：
2006-06-13
期刊：
影响因子：
9.9
通讯作者：
Joo, EY
中科院分区：
文献类型：
--
作者：
Hong, SB;Tae, WS;Joo, EY
为了定位猝倒期间的脑灌注差异，在发作性睡病患者的猝倒和基线清醒期或快速眼动睡眠之间进行脑 SPECT 减法。猝倒期间，减影SPECT显示右侧杏仁核、双侧扣带回、基底神经节、丘脑、前运动皮质、感觉运动皮质、右侧岛叶和脑干灌注过度，而前额皮质和枕叶灌注不足。该结果表明猝倒是由杏仁皮质-基底神经节-脑干回路的激活产生的。
To localize cerebral perfusion differences during cataplexy, brain SPECT subtraction was performed between cataplexy and baseline awake period or REM sleep in patients with narcolepsy. During cataplexy, subtracted SPECT showed hyperperfusion in right amygdala, bilateral cingulate gyri, basal ganglia, thalami, premotor cortices, sensorimotor cortices, right insula, and brainstem, and hypoperfusion in prefrontal cortex and occipital lobe. This result suggests that cataplexy is produced by the activation of amygdalocortico-basal ganglia-brainstem circuit.