Tissue response to chronically stimulated implanted epimysial and intramuscular electrodes.
Tissue response to chronically stimulated implanted epimysial and intramuscular electrodes.
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DOI：
10.1109/86.593301
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发表时间：
1997-06-01
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影响因子：
--
通讯作者：
Merritt, K
中科院分区：
文献类型：
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作者：
Akers, J M;Peckham, P H;Merritt, K
24个肌外膜和16个肌内电极植入5只成年犬，植入时间为11至50个月。在植入期接近结束时，对一半的电极施加慢性刺激8周。通过在电极区域内衬的囊中观察到的纤维组织和炎性细胞的数量和外观来评定组织反应。包囊组织主要由胶原和成纤维细胞以及一些巨噬细胞和少量其他炎性细胞组成。肌外电极在电极之间和电极内表现出更多的变化，但比肌内电极具有更多的更好的评分。对于肌外膜电极，在对照组和刺激组之间测得的分数分布无差异。虽然肌内电极的评分变化很小，但方差足以表明应用慢性刺激时评级较差的趋势。肌外电极下的纤维囊通常比肌内电极周围的纤维囊薄。对于两种电极类型，厚度与慢性刺激的应用或水平无关。研究表明，厚度与用于锚定肌外膜电极的缝线的损失程度正相关。
Twenty-four epimysial and 16 intramuscular electrodes were implanted in five adult dogs for periods ranging from 11 to 50 months. Chronic stimulation was applied to half of the electrodes for eight weeks near the end of the implantation period. The tissue response was rated by the amount and appearance of the fibrous tissue and inflammatory cells seen in the capsule lining the region of the electrode. The encapsulation tissues were composed primarily of collagen and fibroblasts and some macrophages and few other inflammatory cells. The epimysial electrodes exhibited more variation between and within electrodes, but had more of the better scores than the intramuscular electrodes. No difference in the distribution of scores was measured between the control and stimulated groups for the epimysial electrodes. While the scores for the intra-muscular electrodes varied very little, variance was sufficient to indicate a trend for poorer ratings with the application of chronic stimulation. Fibrous capsules were generally thinner under the epimysial electrodes than around the intramuscular electrodes. For both electrode types, the thickness was not correlated with the application or level of chronic stimulation. Thickness was shown to be positively correlated to the degree of loss of the sutures used to anchor the epimysial electrodes.