Cardiovascular disease in patients with rheumatoid arthritis.
Cardiovascular disease in patients with rheumatoid arthritis.
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类风湿关节炎患者的心血管疾病。
DOI：
10.1016/j.tcm.2016.07.006
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发表时间：
2017-02
影响因子：
9.3
通讯作者：
Liao KP
中科院分区：
文献类型：
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作者：
Liao KP
类风湿性关节炎（RA）患者的心血管疾病（CVD）风险比一般人群中年龄和性别匹配的个体高1.5-2倍。这种过度风险归因于全身性慢性炎症，这是RA的标志。优化RA中CV风险管理的挑战包括需要改进预测CV风险的方法，以及定义降低CV风险的目标风险因素。从RA研究中吸取的经验教训也可以为普通人群的CV风险预防提供信息，其中炎症在动脉粥样硬化的发病机制中也起着重要作用。
The risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) is 1.5–2 fold higher than age- and sex- matched individuals from the general population. This excess risk is attributed to the systemic chronic inflammation which is a hallmark of RA. Challenges to optimizing CV risk management in RA include the need for improved methods to predict CV risk, and defining the target risk factor(s) to reduce CV risk. Lessons learned from RA studies can also inform CV risk prevention in the general population, where inflammation also has an important role in the pathogenesis of atherosclerosis.