Insulin sensitivity is correlated with subcutaneous but not visceral body fat in overweight and obese prepubertal children
Insulin sensitivity is correlated with subcutaneous but not visceral body fat in overweight and obese prepubertal children
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DOI：
10.1210/jc.2007-2089
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发表时间：
2008-06-01
影响因子：
5.8
通讯作者：
Bonadonna, Riccardo C.
中科院分区：
文献类型：
--
作者：
Maffeis, Claudio;Manfredi, Riccardo;Bonadonna, Riccardo C.
目的：探讨青春期前儿童胰岛素敏感性、体脂分布、异位(肝脏和骨骼肌)脂肪沉积、脂肪因子(瘦素和脂联素)及炎症标志物(高敏C反应蛋白、IL-6、IL-10和肿瘤坏死因子-α)之间的关系。研究对象与方法：超重肥胖儿童30名，其中男性16名，女性14名，体重指数z值范围1.1~3.2。用磁共振成像技术测量体脂分布及肝脏和骨骼肌脂肪蓄积。结果：胰岛素敏感性与腹部皮下脂肪含量(r=-0.52；P<0.01)和肝脏脂肪含量(r=-0.44；P<；0.02)相关，与内脏脂肪(VAT)(r=-0.193，P值不显著)和骨骼肌脂肪蓄积(r=-0.210，P值不显著)相关。脂肪因子，而不是炎症标记物，与胰岛素敏感性显著相关。VAT与C反应蛋白(r=0.55；P<；0.01)和脂联素(r=-0.53；P<；0.01)呈正相关。多元回归分析显示，只有SAT和肝脏脂肪含量与胰岛素敏感性独立相关(P<；0.01；分别为解释方差的20%和16%)。结论：在超重和中度肥胖的青春期前儿童中，胰岛素敏感性与SAT和肝脏脂肪含量呈负相关。此外，与成人相反，VAT和炎症标记物与儿童的胰岛素敏感性无关。
Aim: Our aim was to explore the relationship between insulin sensitivity, body fat distribution, ectopic (liver and skeletal muscle) fat deposition, adipokines (leptin and adiponectin), and inflammation markers (highly sensitive C-reactive protein, IL-6, IL-10, and TNF-alpha) in prepubertal children. Subjects andMethods: Thirty overweight and obese children (16 males and 14 females with body mass index z-score range of 1.1-3.2) were recruited. Body fat distribution and fat accumulation in liver and skeletal muscle were measured using magnetic resonance imaging. Insulin sensitivity was assessed by iv glucose tolerance test.Results: Insulin sensitivity was associated with sc abdominal adipose tissue (SAT) (r = -0.52; P < 0.01) and liver fat content (r = -0.44; P < 0.02) but not with visceral abdominal adipose tissue (VAT) (r = -0.193; P value not significant) and fat accumulation in skeletal muscle (r = -0.210; P value not significant). Adipokines, but not inflammation markers, were significantly correlated to insulin sensitivity. VAT correlated with C-reactive protein (r = 0.55; P < 0.01) as well as adiponectin (r = -0.53; P < 0.01). Multiple regression analysis showed that only SAT and liver fat content were independently correlated to insulin sensitivity (P < 0.01; 20 and 16% of explained variance, respectively).Conclusions: In overweight and moderately obese prepubertal children, insulin sensitivity was negatively correlated with SAT and liver fat content. Furthermore, contrary to adults, VAT and inflammation markers were not correlated with insulin sensitivity in children.