Amyloid-β, Tau, and 18F-Fluorodeoxyglucose Positron Emission Tomography in Posttraumatic Stress Disorder
Amyloid-β, Tau, and 18F-Fluorodeoxyglucose Positron Emission Tomography in Posttraumatic Stress Disorder
复制标题
DOI：
10.3233/jad-190913
复制
发表时间：
2020-01-01
影响因子：
4
通讯作者：
Rowe, Christopher C.
中科院分区：
文献类型：
--
作者：
Elias, Alby;Cummins, Tia;Rowe, Christopher C.
背景资料：流行病学研究表明创伤后应激障碍（PTSD）和痴呆之间存在关系。目的：本研究评估了患有PTSD的越南退伍军人中阿尔茨海默病（AD）成像生物标志物是否升高。方法：本研究比较了83名患有和不患有PTSD的退伍军人的认知、淀粉样蛋白β、tau蛋白、局部脑代谢和体积，以及APOE的影响。与对照组相比，PTSD组受教育程度、预测发病前智商、颅内总体积和蒙特利尔认知评估评分显著降低。有两组之间没有差异的成像或遗传生物标志物AD。结论：我们的研究结果不支持AD病理和PTSD之间的关联长达50年的时间。与对照组相比，PTSD组评估认知储备（可能延迟痴呆发作的一个因素）的措施较低，这可能是先前观察到的PTSD痴呆发病率较高的原因。
Background: Epidemiological studies suggest a relationship between posttraumatic stress disorder (PTSD) and dementia.Objective: This study assessed whether Alzheimer's disease (AD) imaging biomarkers were elevated in Vietnam veterans with PTSD.Methods: The study compared cognition, amyloid-beta, tau, regional brain metabolism and volumes, and the effect of APOE in 83 veterans with and without PTSD defined by the Clinician-Administered PTSD Scale.Results: The PTSD group had significantly lower education, predicted premorbid IQ, total intracranial volume, and Montreal Cognitive Assessment score compared with the controls. There was no difference between the two groups in the imaging or genetic biomarkers for AD.Conclusion: Our findings do not support an association between AD pathology and PTSD of up to 50 years duration. Measures to assess cognitive reserve, a factor that may delay the onset of dementia, were lower in the PTSD group compared with the controls and this may account for the previously observed higher incidence of dementia with PTSD.