Impaired neural synchrony in the theta frequency range in adolescents at familial risk for schizophrenia.
Impaired neural synchrony in the theta frequency range in adolescents at familial risk for schizophrenia.
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DOI：
10.3389/fpsyt.2011.00051
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发表时间：
2011
影响因子：
4.7
通讯作者：
Belger A
中科院分区：
文献类型：
--
作者：
Donkers FC;Schwikert SR;Evans AM;Cleary KM;Perkins DO;Belger A
青春期是负责执行功能和情感处理的额边缘和额纹脑回路成熟的关键时期。青春期也与精神分裂症前驱症状的出现相吻合，这可能表明这两个过程之间存在关联。对30例健康对照（HC）和24例精神分裂症家族性风险个体的脑电图（EEG）数据进行时域分析和基于小波的时频分析。所有参与者的年龄都在13到18岁之间，并且根据年龄、性别、种族、教育程度和坦纳阶段进行了仔细的匹配。当参与者执行视觉古怪任务时，从32个脑电图通道获得电生理记录，在该任务中，他们在标准的“混乱”图像和罕见的厌恶和中性分心图像中识别罕见的视觉目标。时域分析显示，在目标加工过程中，FR组的P2和P3区事件相关电位较HC组小。此外，FR组在目标加工过程中theta （4-8 Hz）频率范围内的脑电图活动显著减少。青春期皮质信息处理效率低下可能是精神分裂症FR青少年脑功能改变的早期指标，也可能是发病的易感性标志。纵向评估必须确定其在FR人群中对精神病发病的预测价值。
Puberty is a critical period for the maturation of the fronto-limbic and fronto-striate brain circuits responsible for executive function and affective processing. Puberty also coincides with the emergence of the prodromal signs of schizophrenia, which may indicate an association between these two processes. Time-domain analysis and wavelet based time–frequency analysis was performed on electroencephalographic (EEG) data of 30 healthy control (HC) subjects and 24 individuals at familial risk (FR) for schizophrenia. All participants were between the ages of 13 and 18 years and were carefully matched for age, gender, ethnicity, education, and Tanner Stage. Electrophysiological recordings were obtained from 32 EEG channels while participants performed a visual oddball task, where they identified rare visual targets among standard “scrambled” images and rare aversive and neutral distracter pictures. The time-domain analysis showed that during target processing the FR group showed smaller event-related potentials in the P2 and P3 range as compared to the HC group. In addition, EEG activity in the theta (4–8 Hz) frequency range was significantly reduced during target processing in the FR group. Inefficient cortical information processing during puberty may be an early indicator of altered brain function in adolescents at FR for schizophrenia and may represent a vulnerability marker for illness onset. Longitudinal assessments will have to determine their predictive value for illness onset in populations at FR for psychotic illness.