Pericytes as the Orchestrators of Vasculature and Adipogenesis.
Pericytes as the Orchestrators of Vasculature and Adipogenesis.
复制标题
周细胞作为血管系统和脂肪发生的屏障。
作者：
周细胞（PC）位于小血管壁周围，特别是毛细血管和微血管。除了维持血管完整性、参与血管生成和调节血流的功能外，PC还充当白色、棕色、米色和骨髓脂肪组织中多能干/祖细胞的储存库。由于该细胞群的复杂性质，PC的鉴定和表征一直具有挑战性。全面了解PC的异质性可能会增强其作为代谢综合征或骨相关疾病治疗靶点的潜力。这篇简短的综述总结了谱系追踪研究中常用的多种PC标志物，重点是它们在不同代谢条件下对不同脂肪库脂肪形成和功能的贡献。
Pericytes (PCs) are located surrounding the walls of small blood vessels, particularly capillaries and microvessels. In addition to their functions in maintaining vascular integrity, participating in angiogenesis, and regulating blood flow, PCs also serve as a reservoir for multi-potent stem/progenitor cells in white, brown, beige, and bone marrow adipose tissues. Due to the complex nature of this cell population, the identification and characterization of PCs has been challenging. A comprehensive understanding of the heterogeneity of PCs may enhance their potential as therapeutic targets for metabolic syndromes or bone-related diseases. This mini-review summarizes multiple PC markers commonly employed in lineage-tracing studies, with an emphasis on their contribution to adipogenesis and functions in different adipose depots under diverse metabolic conditions.
登录
查看更多内容
DOI：
10.1002/stem.2846
发表时间：
2018-09
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Cathery W;Faulkner A;Maselli D;Madeddu P
通讯作者：
Madeddu P
影响因子：
7.5
作者：
Bora P;Majumdar AS
通讯作者：
Majumdar AS
影响因子：
5.5
作者：
Birbrair, Alexander;Zhang, Tan;Delbono, Osvaldo
通讯作者：
Delbono, Osvaldo
影响因子：
4.8
作者：
Bondjers, Cecilia;He, Liqun;Betsholtz, Christer
通讯作者：
Betsholtz, Christer
影响因子：
16.6
作者：
Berry DC;Jiang Y;Graff JM
通讯作者：
Graff JM