MEROPS: the peptidase database
MEROPS: the peptidase database
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DOI：
10.1093/nar/gkh071
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Barrett, AJ
中科院分区：
文献类型：
--
作者：
Rawlings, ND;Tolle, DP;Barrett, AJ
肽酶（蛋白水解酶）与生物学、医学和生物技术有着重要的关系。这种实际的重要性创造了一个关于他们的信息的综合来源的需要，也对他们的天然抑制剂。MEROPS数据库（merops.sanger.ac.uk）旨在满足这一需求。该数据库的组织原则是分层分类，其中感兴趣的蛋白质的同源集合被分组在家族中，并且同源家族被分组在氏族中。每个肽酶、家族和氏族具有唯一标识符。该数据库最近已扩大到包括蛋白质抑制剂的肽酶，这些被归类在很大程度上相同的方式作为肽酶。最近增加的信息形式包括与其他数据库的新链接、肽酶族的简要比对、显示生物体中肽酶和抑制剂的分布、底物切割位点和含有肽酶的表达序列标签库的索引。一种新的方式，使超链接到数据库已被设计和BlastP搜索我们的图书馆的肽酶和抑制剂序列已被添加。
Peptidases (proteolytic enzymes) are of great relevance to biology, medicine and biotechnology. This practical importance creates a need for an integrated source of information about them, and also about their natural inhibitors. The MEROPS database (http://merops.sanger.ac.uk) aims to fill this need. The organizational principle of the database is a hierarchical classification in which homologous sets of the proteins of interest are grouped in families and the homologous families are grouped in clans. Each peptidase, family and clan has a unique identifier. The database has recently been expanded to include the protein inhibitors of peptidases, and these are classified in much the same way as the peptidases. Forms of information recently added include new links to other databases, summary alignments for peptidase clans, displays to show the distribution of peptidases and inhibitors among organisms, substrate cleavage sites and indexes for expressed sequence tag libraries containing peptidases. A new way of making hyperlinks to the database has been devised and a BlastP search of our library of peptidase and inhibitor sequences has been added.