The Lesions of Porcine Adenoviral Infection in Germfree and Pathogen-Free Pigs
The Lesions of Porcine Adenoviral Infection in Germfree and Pathogen-Free Pigs
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无菌无病原猪腺病毒感染的病变
DOI：
10.1177/030098586700400603
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发表时间：
1967
影响因子：
2.4
通讯作者：
L. Kasza
中科院分区：
文献类型：
--
作者：
J. Shadduck;A. Koestner;L. Kasza
从患有脑炎的猪的脑中分离的猪腺病毒被证明对无菌和无病原体的猪具有致病性。通过5种不同的接种途径产生病变，其中鼻内接种是最有效的。鼻内接种的动物发生间质性肺炎，累及整个小叶，在肺门附近尤其突出。可见明显的核内包涵体。在肾脏、甲状腺和淋巴结中也发现了病变和包涵体。免疫荧光显示病变内有病毒抗原。脑内接种导致仅累及大脑皮层的脊髓灰质炎。这种疾病的许多特征与人类和其他动物的腺病毒疾病相似。
A porcine adenovirus isolated from the brain of a pig with encephalitis was shown to be pathogenic for germfree and pathogen-free pigs. Lesions were produced by 5 different routes of inoculation, of which the intranasal was the most effective. The animals inoculated intranasally developed an interstitial pneumonia which involved entire lobules and was especially prominent near the hilus. Distinct intranuclear inclusion bodies were seen. Lesions and inclusion bodies were also found in the kidneys, thyroids, and lymph nodes. Viral antigen was demonstrated in the lesions by immunofluorescence. Intracerebral inoculation resulted in polioencephalitis involving only the cerebral cortex. Many features of this disease were similar to adenoviral diseases of man and other animal species.