EFFECTS OF ACUTE HEMORRHAGIC HYPOTENSION DURING PREGNANCY AND LACTATION IN CONSCIOUS GOATS
EFFECTS OF ACUTE HEMORRHAGIC HYPOTENSION DURING PREGNANCY AND LACTATION IN CONSCIOUS GOATS
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DOI：
10.1111/j.1365-201x.1987.tb10621.x
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发表时间：
1987-04-01
期刊：
影响因子：
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通讯作者：
THORNSTROM, U
中科院分区：
文献类型：
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作者：
OLSSON, K;ANDEN, NE;THORNSTROM, U
在6只山羊中研究了急性、短暂出血的影响。在分娩前55 ± 3天（妊娠中期= MP）和24 ± 2天（妊娠晚期= LP）、哺乳期第3-8周以及非妊娠、非哺乳（=对照）期进行实验。室温保持在20 ± 1 °C，除了在泌乳山羊中的一个实验系列期间，其在+30 °C下进行。当平均动脉血压（MAP）下降时，在所有时间段中取出了大约相同体积的血液。此时，出血停止了。体积损失，计算为总血量的百分比，是显着小于在妊娠期和哺乳期比对照期。最快的心率，在休息和出血期间，观察LP山羊。LP山羊的呼吸频率在对出血的反应中显著增加，但在室温+30 °C下流血的的泌乳山羊中观察到最快的呼吸频率。血浆加压素（AVP）浓度的增加与MAP的下降相一致。在妊娠晚期观察到的AVP升高显著高于所有其他时期。血浆去甲肾上腺素（NA）浓度在LP山羊中增加了约5倍，但在其他时期没有显着变化。血浆肾素活性没有升高，除了在+30 °C下流血的的泌乳山羊略有增加。血浆醛固酮浓度升高，但各时期之间无差异。提示晚期妊娠出血后动脉血压的恢复需要较高的血浆AVP和NA水平。
Effects of acute, short‐lasting haemorrhage have been studied in six goats. The experiments were made 55 ± 3 days (mid‐pregnancy = MP), and 24 ± 2 days (late pregnancy = LP) before parturition, in lactation weeks 3–8, and in the non‐pregnant, non‐lactating (= control) period. The room temperature was kept at 20 ± 1 °C, except during one experimental series in lactating goats, which was performed at + 30 °C. Approximately the same volume of blood had been removed in all periods, when the mean arterial blood pressure (MAP) fell. At this moment bleeding was stopped. The volume loss, calculated as per cent of total blood volume, was significantly smaller during pregnancy and lactation than in the control period. The fastest heart rate, both at rest and during haemorrhage, was observed in LP goats. The respiratory frequency of the LP goats increased markedly in response to haemorrhage, but the most rapid respiratory rate was observed in lactating goats bled at the room temperature + 30 °C. The increase in plasma vasopressin (AVP) concentration coincided with the fall in MAP. The AVP rise seen during late pregnancy was significantly higher than in all the other periods. The plasma noradrenaline (NA) concentration increased by about five times in LP goats, but did not change significantly in the other periods. Plasma renin activity did not rise, with the exception of a small increase in lactating goats bled at + 30 °C. The plasma aldosterone concentration rose, but there was no difference between periods. It is suggested that higher plasma levels of AVP and NA are needed in order to restore the arterial blood pressure after haemorrhage during late pregnancy.