Collagen and elastic system in the remodelling process of major types of idiopathic interstitial pneumonias (IIP)
Collagen and elastic system in the remodelling process of major types of idiopathic interstitial pneumonias (IIP)
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DOI：
10.1111/j.1365-2559.2005.02103.x
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发表时间：
2005-04-01
期刊：
影响因子：
6.4
通讯作者：
Capelozzi, VL
中科院分区：
文献类型：
--
作者：
Rozin, GF;Gomes, MM;Capelozzi, VL
目的：急性和慢性特发性间质性肺炎（IIP）的结构重塑已经被广泛研究，但很少有人关注这些情况下的弹性组织。本研究的目的是确定在弥漫性肺泡损伤（DAD）、组织性肺炎（OP）、非特异性间质性肺炎（NSIP）和通常间质性肺炎（UIP）这四种主要的IIP组织学模式中，弹性沉积是否伴随胶原沉积。方法和结果：通过图像分析，我们分别使用picrosirius偏振法和Weigert的间瘤素-紫红染色法测量肺活检组织学切片中肺泡间隔胶原和弹性系统的纤维含量。分为5组：10例DAD；OP 9例；NSIP 9例；10例UIP。4个正常肺作为对照。与DAD、NSIP、OP和正常肺相比，UIP中胶原纤维含量显著升高。与正常肺相比，弹性纤维含量增加，但在组织学模式中无显著差异。结论：急性和慢性IIP引起肺部胶原蛋白和弹性含量相似的增加，代表“纤维弹性增生”的过程，而不是纤维化的唯一过程。在UIP受试者中观察到的无与伦比的胶原蛋白增加，其性质尚待确定，其纤维化机制是负责的。
Aims: Structural remodelling in acute and chronic idiopathic interstitial pneumonia (IIP) has been extensively investigated, but little attention has been directed to the elastic tissue in these situations. The aim of this study was to determine whether elastic deposition accompanies collagen deposition in the four major histological patterns of IIP: diffuse alveolar damage (DAD), organizing pneumonia (OP), non-specific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP).Methods and results: We measured, by image analysis, the content of fibres of the collagenous and elastic systems of the alveolar septum in histological slides of open lung biopsies, using the picrosirius-polarization method and Weigert's resorcin-fuchsin stain, respectively. Five groups were studied: 10 cases of DAD; nine cases of OP; nine cases of NSIP; and 10 cases of UIP. Four normal lungs were used for comparison. The content of collagen fibres was significantly higher in UIP when compared to DAD, NSIP, OP and normal lung. The content of elastic fibres was increased in comparison with normal lungs but this was not significantly different among the histological patterns.Conclusion: Acute and chronic IIP cause a similar increase in the collagen and elastic contents of the lungs, representing a process of 'fibroelastosis' rather than an exclusive process of fibrosis. A profibrogenic mechanism is responsible for the unparallelled collagen augmentation observed in UIP subjects, the nature of which is yet to be determined.