Integrated acoustic and magnetic separation in microfluidic channels
Integrated acoustic and magnetic separation in microfluidic channels
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DOI：
10.1063/1.3275577
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发表时间：
2009-12-21
影响因子：
4
通讯作者：
Soh, H. Tom
中科院分区：
文献类型：
--
作者：
Adams, Jonathan D.;Thevoz, Patrick;Soh, H. Tom
随着越来越多的基于细胞的生物技术应用，需要能够以高纯度和通量进行多参数分离的颗粒分离系统，这超出了目前由包括荧光激活细胞分选和基于柱的磁性分离的传统方法所提供的。为了这个目标，我们报告的集成微流控声和磁分离在一个整体设备的多参数颗粒分离。使用我们的设备，我们展示了高纯度的多组分颗粒混合物的分离，通量高达10（8）粒子/小时。（C）2009年美国物理研究所。[doi：10.1063/1.3275577]
With a growing number of cell-based biotechnological applications, there is a need for particle separation systems capable of multiparameter separations at high purity and throughput, beyond what is presently offered by traditional methods including fluorescence activated cell sorting and column-based magnetic separation. Toward this aim, we report on the integration of microfluidic acoustic and magnetic separation in a monolithic device for multiparameter particle separation. Using our device, we demonstrate high-purity separation of a multicomponent particle mixture at a throughput of up to 10(8) particles/hr. (C) 2009 American Institute of Physics. [doi:10.1063/1.3275577]