Compartmentalized organization: a common and required feature of stem cell niches?
Compartmentalized organization: a common and required feature of stem cell niches?
复制标题
DOI：
10.1242/dev.041103
复制
发表时间：
2010-05-15
期刊：
影响因子：
4.6
通讯作者：
Guo, Shangqin
中科院分区：
文献类型：
--
作者：
Greco, Valentina;Guo, Shangqin
干细胞领域的一个关键问题是如何在干细胞的缓慢细胞周期与活跃的器官生长之间取得平衡。近期对毛囊干细胞微环境的研究表明，这可以通过将干细胞微环境组织成两个部分来实现：一个参与即时、快速的新生长，另一个随后对促进毛发再生的长期生长起作用。基于这些以及其他近期的发现，我们提出，其他几种成体干细胞微环境，包括血液、肠道和大脑中的那些，具有类似的双区室结构，并且干细胞可能与其后代协同作用以维持组织再生。
A key question in the stem cell field is how to balance the slow cycling of stem cells with active organ growth. Recent studies of the hair follicle stem cell niche have shown that this can be achieved by organizing the stem cell niche into two compartments: one that engages in immediate, rapid new growth and one that contributes later to long-term growth that fuels hair regeneration. Based on these and other recent findings, we propose that several other adult stem cell niches, including those in the blood, intestine and brain, have a similar bi-compartmental organization and that stem cells might work cooperatively with their progeny to sustain tissue regeneration.