Change in Drusen Area Over Time Compared Using Spectral-Domain Optical Coherence Tomography and Color Fundus Imaging
Change in Drusen Area Over Time Compared Using Spectral-Domain Optical Coherence Tomography and Color Fundus Imaging
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DOI：
10.1167/iovs.14-15273
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发表时间：
2014-11-01
影响因子：
4.4
通讯作者：
Rosenfeld, Philip J.
中科院分区：
文献类型：
--
作者：
Gregori, Giovanni;Yehoshua, Zohar;Rosenfeld, Philip J.
目的.探讨彩色眼底图像（CFIs）测量玻璃疣面积与光谱域光学相干断层扫描（SDOCT）测量玻璃疣面积的关系。前瞻性研究招募了30例玻璃疣患者的42只眼，无地图样萎缩。在基线和3个月和6个月随访时获得数字彩色眼底图像和SDOCT图像。在CFI和SDOCT图像上识别出以中心凹为中心的直径为3 mm和5 mm的配准匹配圆。使用市售的专有算法获得光谱域OCT玻璃疣测量值。在Doheny眼科研究所图像阅读中心手动追踪CFI上的玻璃疣边界。SDOCT图像上3 mm圆的玻璃疣面积（SQDA）测量值在基线时为1.451 mm，在第26周时为1.464 mm，而CFI上的测量值在基线时为1.555 mm，在第26周时为1.584 mm。在所有时间点，CFI的平均SQDA测量值均大于SDOCT测量值（基线时P = 0.004，26周时P = 0.003）。26周内，SDOCT测量的SQDA变化与CFI测量的SQDA变化无差异（平均差异= 0.014 mm，P = 0.5）。光谱域OCT玻璃疣面积测量值小于从CFI获得的测量值。然而，两种成像方式之间玻璃疣面积随时间的变化没有差异。频域OCT测量在评估玻璃疣面积变化方面更为敏感。
PURPOSE. To investigate the relationship between drusen areas measured with color fundus images (CFIs) and those with spectral- domain optical coherence tomography (SDOCT).METHODS. Forty-two eyes from thirty patients with drusen in the absence of geographic atrophy were recruited to a prospective study. Digital color fundus images and SDOCT images were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the fovea with diameters of 3 mm and 5 mm were identified on both CFIs and SDOCT images. Spectral-domain OCT drusen measurements were obtained using a commercially available proprietary algorithm. Drusen boundaries on CFIs were traced manually at the Doheny Eye Institute Image Reading Center.RESULTS. Mean square root drusen area (SQDA) measurements for the 3-mm circles on the SDOCT images were 1.451 mm at baseline and 1.464 mm at week 26, whereas the measurements on CFIs were 1.555 mm at baseline and 1.584 mm at week 26. Mean SQDA measurements from CFIs were larger than those from the SDOCT measurements at all time points (P = 0.004 at baseline, P = 0.003 at 26 weeks). Changes in SQDA over 26 weeks measured with SDOCT were not different from those measured with CFIs (mean difference = 0.014 mm, P = 0.5).CONCLUSIONS. Spectral-domain OCT drusen area measurements were smaller than the measurements obtained from CFIs. However, there were no differences in the change in drusen area over time between the two imaging modalities. Spectral-domain OCT measurements were considerably more sensitive in assessing drusen area changes.