Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus
Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus
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DOI：
10.1152/ajpheart.00403.2003
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发表时间：
2003-12-01
影响因子：
4.8
通讯作者：
Creager, MA
中科院分区：
文献类型：
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作者：
Beckman, JA;Goldfine, AB;Creager, MA
氧化应激降低糖尿病患者内皮源性一氧化氮的生物利用度。我们研究了糖尿病患者内皮依赖性血管舒张功能（EDV）受损是否可以通过长期口服抗氧化剂来改善。49名糖尿病受试者[26名1型（T1）和23名2型（T2）]和45名匹配的健康对照受试者随机接受口服维生素C（1，000 mg）和维生素E（800 IU）每日或匹配的安慰剂治疗6个月。血管超声检查测定肱动脉EDV和内皮非依赖性血管舒张功能（EIV）。EDV在T1（4.9 ± 0.9%，P=0.015）和T2（4.1 ± 1.0%，P
Oxidative stress decreases the bioavailability of endothelium-derived nitric oxide in diabetic patients. We investigated whether impaired endothelium-dependent vasodilation (EDV) in diabetes can be improved by long-term administration of oral antioxidants. Forty-nine diabetic subjects [26 Type 1 (T1) and 23 Type 2 (T2)] and 45 matched healthy control subjects were randomized to receive oral vitamin C (1,000 mg) and vitamin E (800 IU) daily or matching placebo for 6 mo. Vascular ultrasonography was used to determine brachial artery EDV and endothelium-independent vasodilation (EIV). EDV was decreased in both T1 (4.9+/-0.9%, P=0.015) and T2 (4.1+/-1.0%, P