Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae and Escherichia coli isolates possessing blaVIM-1 in Greece
Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae and Escherichia coli isolates possessing blaVIM-1 in Greece
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DOI：
10.1016/j.ijantimicag.2010.05.004
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发表时间：
2010-09-01
影响因子：
10.8
通讯作者：
Giamarellou, H.
中科院分区：
文献类型：
--
作者：
Galani, I.;Souli, M.;Giamarellou, H.
在从Attikon大学综合医院（雅典，希腊）的住院患者和门诊患者中回收的耐萘啶酸、环丙沙星敏感的大肠埃希菌和肺炎克雷伯菌临床分离株中，仅1株大肠埃希菌。coli中qnrB 2和1株K. pneumoniae为qnrA 1阳性。两种分离株均为超广谱β-内酰胺酶阴性，金属β-内酰胺酶阳性，并携带bla（Vim-1）基因。这两个分离株都没有gyrA和parC突变，也没有携带aac（6 '）-Ib-cr或qepA。酸克雷pneumoniae分离物也在与qnrA 1相同的可转移质粒上携带bla（CMY-13）。这是首次报道qnrA 1阳性的克雷伯菌。pneumoniae和qnrB 2阳性E.大肠杆菌中同时含有bla（Vim-1）基因。(C)2010年Elsevier B. V.和国际化疗学会。All rights reserved.
Amongst nalidixic acid-resistant, ciprofloxacin-susceptible Escherichia coli and Klebsiella pneumoniae clinical isolates recovered over a 5-month period from inpatients and outpatients of Attikon University General Hospital (Athens, Greece), only one E. coli was positive for qnrB2 and one K. pneumoniae was positive for qnrA1. Both isolates were extended-spectrum beta-lactamase-negative, metallo-beta-lactamase-positive and carried the bla(VIM-1) gene. Neither of the isolates had mutations in gyrA and parC or carried aac(6')-Ib-cr or qepA. The K. pneumoniae isolate also harboured bla(CMY-13) on the same transferable plasmid with qnrA1. This is the first report of a qnrA1-positive K. pneumoniae and qnrB2-positive E. coli harbouring a concurrent bla(VIM-1) gene. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.