Trauma, Metabolomics, Outcomes, and Secrets of the Sphinx.
Trauma, Metabolomics, Outcomes, and Secrets of the Sphinx.
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DOI：
10.1016/j.jamcollsurg.2021.02.002
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发表时间：
2021-05
影响因子：
5.2
通讯作者：
Pritts TA
中科院分区：
文献类型：
--
作者：
Pritts TA
创伤仍然是所有年龄组死亡的主要原因，随着人口老龄化，其全球影响越来越大。1院前护理、损伤控制手术和基于血液的损伤控制复苏的进步显著改善了严重损伤后失血的初始生存率，2但这些患者通常病情危重，并存在持续后遗症的风险，包括器官衰竭，3慢性危重病的发展，4和损伤后的晚期死亡率。5，6尽管持续不断的努力，复苏后生理学和代谢功能的许多方面，更重要的是，改善结果的潜在机会，仍然没有完全了解。Cyr及其同事7的这项研究是及时和有启发性的。作者对受伤患者的血清进行了大规模的综合代谢组学分析，然后分析了代谢组随时间的变化，使用具有等级排序的共识方法对代谢物进行优先排序以进行进一步审查。几乎一半的代谢产物由脂质组成。作者发现，随着时间的推移，鞘脂表达模式发生了特定变化，在创伤后早期增加了鞘氨醇和鞘氨醇种类，随后在后期时间点富集了神经酰胺。他们还发现在每个时间点鞘磷脂富集。为了进一步分析，作者评价了第2天至第5天鞘脂种类的变化。他们证明了特定的鞘脂反应模式与循环细胞因子水平以及钝性创伤后改善的结果相关。鞘氨醇最初发现于19世纪80年代，以狮身人面像命名，狮身人面像是一种神秘的神话生物，是人类，猎鹰，猫，鹰和狮子的一部分。8我们现在知道，鞘氨醇是一个鞘脂大家族的成员，其特征是具有共同的鞘氨醇骨架，加上不同的头部和尾部基团，导致数百个单独的鞘脂类别，每个类别都具有不同的结构和功能。9神经酰胺由鞘氨醇和脂肪酸组成，是所有鞘脂途径的核心，代表了一个重要的神经酰胺家族。
Trauma remains a leading cause of mortality in all age groups, with an increasing global impact as the population ages. 1 Advances in pre-hospital care, damage control surgery, and blood-based damage control resuscitation have led to significant improvement in initial survival from exsanguination after serious injury, 2 but these patients often remain critically ill and are at risk for ongoing sequelae, including organ failure, 3 development of chronic critical illness, 4 and late mortality after injury. 5, 6 Despite intensive ongoing efforts, many aspects of postresuscitation physiology and metabolic function, and, more importantly, potential opportunities to improve outcomes, remain incompletely understood. This study by Cyr and colleagues 7 is timely and enlightening. The authors performed a large-scale comprehensive metabolomic analysis on serum from injured patients, then analyzed the metabolome for changes over time, prioritizing metabolites for further scrutiny using a consensus approach with rank ordering. Almost half of the metabolites examined consisted of lipids. The authors found specific changes in the pattern of sphingolipid expression over time, with increased sphinganine and sphingosine species early after trauma, followed by enrichment of ceramides in the later timepoints. They also found sphingomyelin enrichment at each time point. To take their analysis a step further, the authors evaluated alterations of sphingolipid species at days 2 through 5. They demonstrate that specific sphingolipid response patterns are associated with circulating cytokine levels as well as improved outcomes after blunt trauma.Sphingosine was initially discovered in the 1880s and named after the Sphinx, an enigmatic mythological creature that is part human, falcon, cat, eagle, and lion. 8 We now understand that sphingosine is a member of a large family of sphingolipids, which are characterized by a common sphingoid backbone, with the addition of different head and tail groups, leading to hundreds of individual classes of sphingolipids, each with distinct structures and functions. 9 Ceramide, composed of sphingosine with the addition of a fatty acid, is central to all sphingolipid pathways and represents an important family of
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DOI：
10.1097/ta.0000000000000930
发表时间：
2016-02
期刊：
The journal of trauma and acute care surgery
影响因子：
--
作者：
Callcut RA;Wakam G;Conroy AS;Kornblith LZ;Howard BM;Campion EM;Nelson MF;Mell MW;Cohen MJ
通讯作者：
Cohen MJ
影响因子：
4.7
作者：
Peng, Huiming;Li, Cao;Kadow, Stephanie;Henry, Brian D.;Steinmann, Joerg;Becker, Katrin Anne;Riehle, Andrea;Beckmann, Natalie;Wilker, Barbara;Li, Pin-Lan;Pritts, Timothy;Edwards, Michael J.;Zhang, Yang;Gulbins, Erich;Grassme, Heike
通讯作者：
Grassme, Heike
DOI：
10.33594/000000040
发表时间：
2019-01-01
期刊：
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
影响因子：
--
作者：
Xia, Brent T;Beckmann, Nadine;Caldwell, Charles C
通讯作者：
Caldwell, Charles C
影响因子：
7.3
作者：
Skácel J;Slusher BS;Tsukamoto T
通讯作者：
Tsukamoto T
影响因子：
5.5
作者：
Rice, Teresa C.;Seitz, Aaron P.;Caldwell, Charles C.
通讯作者：
Caldwell, Charles C.