Factors Associated with Lower Cognitive Performance Scores Among Older Japanese Men in Hawaii and Japan
Factors Associated with Lower Cognitive Performance Scores Among Older Japanese Men in Hawaii and Japan
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DOI：
10.3233/jad-201084
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发表时间：
2021-01-01
影响因子：
4
通讯作者：
Masaki, Kamal
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文献类型：
--
作者：
Miyagawa, Naoko;Ohkubo, Takayoshi;Masaki, Kamal
背景资料：很少有研究比较了具有相似遗传背景但生活方式不同的人群中与认知功能相关的因素。目的：我们的目的是确定与两个遗传相似的队列中暴露于不同生活方式因素的日本老年男性认知评分较低相关的因素。方法：这项对71-81岁的日本社区居住男性的横断面研究包括2，628名男性入组了位于夏威夷的Kuakini Honolulu-Asia老龄化研究，349名男性入组了位于日本的亚临床动脉粥样硬化滋贺流行病学研究。我们通过认知能力筛选工具（CASI）评估比较了参与者在夏威夷（1991-1993）和日本（2009-2014）的表现。通过问卷调查和测量确定与低认知评分相关的因素（心血管疾病史、心脏代谢因素和生活方式因素）。采用多变量logistic回归分析，计算不同因素对低（< 82）CASI评分的调整优势比（OR）。夏威夷的CASI评分低于日本[21.2%（n = 556）vs 12.3%（n = 43），p < 0.001]，尽管在调整年龄和教育程度后，这一点并不显著（夏威夷为20.3%，日本为17.9%，p = 0.328）。在夏威夷，卒中史（OR = 1.65，95%置信区间= 1.19-2.29）与低认知评分呈正相关。在日本，体重指数>= 25 kg/m2的人群往往与认知得分低相关;队列之间存在显著的相互作用。结论：队列之间认知得分的差异主要由受教育程度的差异来解释。相反，心血管疾病和心脏代谢因素对遗传相似的老年男性暴露于不同的生活方式因素的认知评分有不同的影响。
Background: Fewstudies have compared factors related to cognitive function among people with similar genetic backgrounds but different lifestyles.Objective: We aimed to identify factors related to lower cognitive scores among older Japanese men in two genetically similar cohorts exposed to different lifestyle factors.Methods: This cross-sectional study of community-dwelling Japanese men aged 71-81 years included 2,628 men enrolled in the Kuakini Honolulu-Asia Aging Study based in Hawaii and 349 men in the Shiga Epidemiological Study of Subclinical Atherosclerosis based in Japan. We compared participant performance through Cognitive Abilities Screening Instrument (CASI) assessment in Hawaii (1991-1993) and Japan (2009-2014). Factors related to low cognitive scores (history of cardiovascular disease, cardiometabolic factors, and lifestyle factors) were identified with questionnaires and measurements. Multivariable logistic regression analysis was used to calculate the adjusted odds ratios (ORs) of a low (< 82) CASI score based on different factors.Results: CASI scores were lower in Hawaii than in Japan [21.2% (n = 556) versus 12.3% (n = 43), p < 0.001], though this was not significant when adjusted for age and educational attainment (Hawaii 20.3% versus Japan 17.9%, p = 0.328). History of stroke (OR = 1.65, 95% confidence interval = 1.19-2.29) was positively associated with low cognitive scores in Hawaii. Body mass index >= 25 kg/m(2) tended to be associated with low cognitive scores in Japan; there was a significant interaction between the cohorts.Conclusion: Cognitive scores differences between cohorts were mostly explained by differences in educational attainment. Conversely, cardiovascular diseases and cardiometabolic factors differentially impacted cognitive scores among genetically similar older men exposed to different lifestyle factors.