Milk Inhibits the Regression of 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Ovariectomized Rats
Milk Inhibits the Regression of 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Ovariectomized Rats
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DOI：
10.1080/01635580801927452
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发表时间：
2008-06
期刊：
影响因子：
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通讯作者：
L. Qin;Jia-Ying Xu;H. Tezuka;Pei-yu Wang;K. Hoshi
中科院分区：
文献类型：
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作者：
L. Qin;Jia-Ying Xu;H. Tezuka;Pei-yu Wang;K. Hoshi
关于牛奶摄入量和乳腺癌风险之间的关系，流行病学研究得出了不一致的结果。本研究采用7，12-二甲基苯并(A)菲诱发大鼠乳腺肿瘤。当肿瘤发展到可接受的水平时，将大鼠分成3个治疗组中的一个。阴性对照组和牛奶组大鼠去卵巢，阳性对照组大鼠假手术。分组后，阳性对照组肿瘤发生率仍为100%，肿瘤数目和体积均有增加。然而，两个卵巢切除组的肿瘤消退。与阴性对照组相比，牛奶组大鼠的肿瘤发生率、肿瘤个数和体积分别从第6周和第4周开始显著增加。在尸检中，牛奶组的胰岛素样生长因子-I水平明显高于阴性对照组。虽然血浆17β-雌二醇水平没有显著差异，但由于牛奶组子宫重量显著高于阴性对照组，因此牛奶组具有雌激素活性。综上所述，商品奶抑制了去卵巢大鼠致癌物诱导的乳腺肿瘤的消退。
Epidemiological studies have yielded inconsistent results regarding the relation between the milk consumption and breast cancer risk. In this study, rats were induced mammary tumors by 7,12-dimethylbenz(a)anthracene. When tumors developed to acceptable levels, rats were placed into 1 of 3 treatment groups. Those in the negative control group and the milk group were ovariectomized, whereas those in the positive control group were sham operated. After grouping, tumor incidence remained 100%, and tumor number and volume increased in the positive control group. However, tumors in the 2 ovariectomized groups regressed. Compared with the negative control group, tumor incidence and tumor number and volume per rat in the milk group became significantly higher from Week 6 and Week 4, respectively. Insulin-like growth factor-I levels were borderline significantly higher in the milk group than in the negative control group at autopsy. Although plasma 17β-estradiol levels did not differ significantly, estrogenicity was found in the milk group because uterine weight was significantly heavier in the milk group than in the negative control group. In conclusion, commercial milk inhibited the regression of carcinogen-induced mammary tumors in ovariectomized rats.