Development of male genital lichen sclerosus in penile reconstruction skin grafts after cancer surgery: an unreported complication
Development of male genital lichen sclerosus in penile reconstruction skin grafts after cancer surgery: an unreported complication
复制标题
DOI：
10.1111/j.1464-410x.2011.10368.x
复制
发表时间：
2012-03-01
影响因子：
4.5
通讯作者：
Greene, Damien R.
中科院分区：
文献类型：
--
作者：
Abdelbaky, Ather M.;Aluru, Pavan;Greene, Damien R.
目的探讨恶性肿瘤术后阴茎重建术中非生殖器皮肤移植的男性生殖器硬化地衣（LS）的发生情况。患者与方法1997年至2009年间，英格兰东北部地区阴茎癌中心——桑德兰皇家医院泌尿外科共有177例患者接受了阴茎癌手术治疗。有保留器官手术和非生殖器阴茎移植重建的患者被确定。对这些移植标本的组织学报告进行了回顾，以确定男性生殖器LS的存在和鳞状细胞癌（SCC）的复发发生率。结果患者诊断时平均年龄（范围）为61.8岁（32 ~ 89岁）。在177例患者中，139例为SCC， 32例为原位癌，6例为疣状癌。总共有56例阴茎重建手术使用从大腿内侧获得的厚皮片。从这些移植物中，获得了18个标本，用于美容、诊断或治疗目的。18例患者中有6例出现男性生殖器LS，其中1例伴有复发性疣状癌。结论：这是首次发表的系列文章，描述了阴茎癌手术后远处阴茎皮肤移植的男性生殖器LS的发生率。这些结果提供了新的信息，可能有助于解释男性生殖器LS的病因。
OBJECTIVETo describe the incidence of the development of male genital lichen sclerosus (LS) in non-genital skin grafts used in penile reconstruction after cancer surgery.PATIENTS AND METHODSBetween 1997 and 2009, 177 patients received surgical treatment for penile cancer in the Urology Department at Sunderland Royal Hospital, the regional penile cancer centre for the north-east of England.Patients who had organ-sparing surgery and non-genital penile graft reconstructions were identified.Histology reports for specimens obtained from those grafts were reviewed to identify the presence of male genital LS and the incidence of recurrence of squamous cell carcinoma (SCC).RESULTSThe mean (range) age of patients at diagnosis was 61.8 (32-89) years. Of the 177 patients, 139 had SCC, 32 had carcinoma in situ and six had verrucous carcinoma.In total, 56 penile reconstructive procedures were performed using split-thickness skin grafts obtained from the inner thigh.From those grafts, 18 specimens were obtained later for cosmetic, diagnostic or curative purposes.Male genital LS was found in six of the 18 specimens, and one of them was associated with recurrent verrucous carcinoma.CONCLUSIONSThis is the first published series to describe the incidence of male genital LS in penile skin grafts taken from a remote site after penile cancer surgery.These results represent new information that might help explain the aetiology of male genital LS.