Probiotics-supplemented feeding in extremely low-birth-weight infants
Probiotics-supplemented feeding in extremely low-birth-weight infants
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DOI：
10.1038/jp.2011.51
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发表时间：
2012-04-01
影响因子：
2.9
通讯作者：
Soll, R.
中科院分区：
文献类型：
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作者：
Al-Hosni, M.;Duenas, M.;Soll, R.
目的：本试验的目的是通过降低经后34周（PMA）时体重低于第10百分位数的婴儿的百分比来测试补充益生菌的喂养极低出生体重（ELBW）婴儿是否会改善生长。其他重要的结果的措施，如提高喂养耐受性确定的耐受性更大的喂养量，每天和减少抗菌治疗天数在第一个28天从开始喂养supplementation.Study设计：我们进行了多中心随机对照双盲临床研究。益生菌补充（PS）组接受添加到第一次肠道喂养的Ladobadllus rbanmosus GG和Biobaderium baderium，并继续每天一次，此后喂养，直到出院或直到34周（PMA）。对照组（C）接受无补充饲料。在研究期的前28天内，每天记录婴儿体重和喂养量。结果：共纳入101例婴儿（PS 50 vs C 51），均在出生后34周测量体重.两组在34周PMA时体重低于第10百分位数的婴儿百分比（PS组58% vs C组60%，P值0.83）或研究入组后28天内的平均喂养量（PS组59 ml/kg vs C组71 ml/kg，P值0.11）方面无差异。PS组的计算生长速度高于C组（14.9 vs 12.6 g/天，P值0.05）。坏死性小肠结肠炎（NEC）的发病率，以及死亡率之间的两个groups.Conclusion：虽然益生菌补充喂养提高生长速度在ELBW婴儿，有没有改善的婴儿生长延迟的百分比在34周PMA。未报告益生菌相关不良事件。Journal of Perinalology（2012）32，253-259; doi：10.1038/jp.2011.51; 2011年5月5日在线发表
Objective: The objective of this trial was to test whether probiotic-supplemented feeding to extremely low-birth-weight (ELBW) infants will improve growth as determined by decreasing the percentage of infants with weight below the 10th percentile at 34 weeks postmenstrual age (PMA). Other important outcome measures, such as improving feeding tolerance determined by tolerating larger volume of feeding per day and reducing antimicrobial treatment days during the first 28 days from the initiation of feeding supplementation were also evaluated.Study Design: We conducted a multicenter randomized controlled double-blinded clinical study. The probiotics-supplementation (PS) group received Ladobadllus rbanmosus GG and Bifidobaderium infantis added to the first enteral feeding and continued once daily with feedings thereafter until discharge or until 34 weeks (PMA). The control (C) group received unsupplemented feedings. Infant weight and feeding volumes were recorded daily during the first 28 days of study period. Weights were also recorded at 34 weeks PMA.Result: A total of 101 infants were enrolled (PS 50 versus C 51). There was no difference between the two groups in the percentage of infants with weight below the 10th percentile at 34 weeks PMA (PS group 58% versus C group 60%, (P value 0.83)) or in the average volume of feeding during 28 days after study entry (PS group 59 ml kg(-1) versus C group 71 ml kg(-1) (P value 0.11)). Calculated growth velocity was higher in the PS group compared with the C group (14.9 versus 12.6 g per day, (P value 0.05)). Incidences of necrotizing enterocolitis (NEC), as well as mortality were similar between the two groups.Conclusion: Although probiotic-supplemented feedings improve growth velocity in ELBW infants, there was no improvement in the percentage of infants with growth delay at 34 weeks PMA. There were no probiotic-related adverse events reported. journal of Perinalology (2012) 32, 253-259; doi:10.1038/jp.2011.51; published online 5 May 2011