Teicoplanin, antibiotics from Actinoplanes teichomyceticus nov. sp. VI. Chemical degradation: physico-chemical and biological properties of acid hydrolysis products.
Teicoplanin, antibiotics from Actinoplanes teichomyceticus nov. sp. VI. Chemical degradation: physico-chemical and biological properties of acid hydrolysis products.
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替考拉宁，来自 Actinoplanes teichomyceticus nov 的抗生素。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
B. Cavalleri
中科院分区：
文献类型：
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作者：
A. Malabarba;P. Strazzolini;A. Depaoli;M. Landi;M. Berti;B. Cavalleri
替考拉宁是一种抗生素复合物，由5种密切相关的因子T-A2-1、2、3、4和5以及极性更强的因子T-A3-1组成。通过控制酸水解，复合物转化为假苷元，最后转化为单一苷元，连续去除三个糖单元。通过降解反应和NMR/LC-MS研究对合适的衍生物进行的糖的定量测定证实，所有组分都携带一个N-酰基-D-葡糖胺，并且其中至少两个组分的特征在于D-葡糖胺单元上的N-癸酰基和N-十一烷酰基链。水解产物仍具有体外和体内活性。
Teicoplanin is an antibiotic complex consisting of five closely related factors, T-A2-1, 2, 3, 4 and 5 and a more polar factor, T-A3-1. By controlled acid hydrolysis the complex is transformed into pseudoaglycones and finally into a single aglycone with consecutive removal of three sugar units. Quantitative determination of sugars obtained by degradative reactions and NMR/LC-MS studies on suitable derivatives confirmed that all the components carry one N-acyl-D-glucosamine and that at least two of them are characterized by N-decanoyl and N-undecanoyl chains on the D-glucosamine unit. The hydrolysis products still possess in vitro and in vivo activity.
抗生素阿伏霉素的核磁共振研究，与抗菌活性相关的构象特性。
影响因子：
3.6
作者：
Fesik,SW;Armitage,IM;Ellestad,GA;McGahren,WJ
通讯作者：
McGahren,WJ