Vestibular ablation and a semicircular canal prosthesis affect postural stability during head turns.
Vestibular ablation and a semicircular canal prosthesis affect postural stability during head turns.
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前庭消融和半规管假体会影响头部转动时的姿势稳定性。
DOI：
10.1007/s00221-016-4722-5
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发表时间：
2016
影响因子：
2
通讯作者：
Lewis,RichardF
中科院分区：
文献类型：
--
作者：
Thompson,LaraA;Haburcakova,Csilla;Lewis,RichardF
在我们的研究中，我们测试了两只恒河猴在转头时的姿势稳定性：一项动物研究对比了正常和轻度双侧前庭消融，另一项动物研究对比了重度双侧前庭消融加和不加假体刺激。猴子们自由地站在平衡台上，不受约束地在视觉目标之间随意地转头。为了量化每只动物的姿势，测量了头部和躯干的运动，以及围绕身体质心的扭矩。在轻度消融的动物中，我们观察到与正常状态相比，前干摆动较小。当假体向严重消融的动物提供电刺激时，它显示出在转头时躯干摇摆的减少。由于双侧前庭严重丧失的恒河猴在接受前庭假体刺激时躯干摇摆减少，我们认为假体电刺激部分恢复了头部的速度信息。我们的结果表明，半规管假体可能是改善严重外周前庭功能障碍患者姿势稳定性的有效方法。
In our study, we examined postural stability during head turns for two rhesus monkeys: one animal study contrasted normal and mild bilateral vestibular ablation and a second animal study contrasted severe bilateral vestibular ablation with and without prosthetic stimulation. The monkeys freely stood, unrestrained on a balance platform and made voluntary head turns between visual targets. To quantify each animals’ posture, motions of the head and trunk, as well as torque about the body’s center of mass, were measured. In the mildly ablated animal, we observed less foretrunk sway in comparison with the normal state. When the canal prosthesis provided electric stimulation to the severely ablated animal, it showed a decrease in trunk sway during head turns. Because the rhesus monkey with severe bilateral vestibular loss exhibited a decrease in trunk sway when receiving vestibular prosthetic stimulation, we propose that the prosthetic electrical stimulation partially restored head velocity information. Our results provide an indication that a semicircular canal prosthesis may be an effective way to improve postural stability in patients with severe peripheral vestibular dysfunction.