Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization.
Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization.
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DOI：
10.1016/j.immuni.2018.06.009
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发表时间：
2018-08-21
期刊：
影响因子：
32.4
通讯作者：
Park GY
中科院分区：
文献类型：
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作者：
Moon HG;Kim SJ;Jeong JJ;Han SS;Jarjour NN;Lee H;Abboud-Werner SL;Chung S;Choi HS;Natarajan V;Ackerman SJ;Christman JW;Park GY
Airway epithelial cells (AECs) secrete innate immune cytokines that regulate adaptive immune effector cells. In allergen sensitized humans and mice, the airway and alveolar microenvironment is enriched with colony stimulating factor-1 (CSF1) in response to allergen exposure. In this study we found that AEC-derived CSF1 had a critical role in the production of allergen reactive-IgE production. Furthermore, spatiotemporally secreted-CSF1 regulated the recruitment of alveolar dendritic cells (DCs) and enhanced the migration of conventional DC2 (cDC2) to the draining lymph node in an interferon regulatory factor 4 (IRF4) dependent manner. CSF1 selectively upregulated the expression of the chemokine receptor CCR7 on the CSF1R+cDC2, but not the cDC1, population in response to allergen stimuli. Our data describe the functional specification of CSF1-dependent DC subsets that link the innate and adaptive immune responses in T helper-2 (Th2) cell-mediated allergic lung inflammation.
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DOI：
10.4049/jimmunol.1102613
发表时间：
2012-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
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Kovats S
DOI：
10.1073/pnas.1019378108
发表时间：
2011-03-29
影响因子：
11.1
作者：
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Iwasaki, Akiko
影响因子：
25
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Madisen L;Zwingman TA;Sunkin SM;Oh SW;Zariwala HA;Gu H;Ng LL;Palmiter RD;Hawrylycz MJ;Jones AR;Lein ES;Zeng H
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Zeng H
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DOI：
10.4049/jimmunol.1600777
发表时间：
2017-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Patel VI;Booth JL;Duggan ES;Cate S;White VL;Hutchings D;Kovats S;Burian DM;Dozmorov M;Metcalf JP
通讯作者：
Metcalf JP
影响因子：
30.5
作者：
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