Brain Morphology in Autism and Fragile X Syndrome Correlates With Social IQ: First Report From the Canadian-Swiss-Egyptian Neurodevelopmental Study
Brain Morphology in Autism and Fragile X Syndrome Correlates With Social IQ: First Report From the Canadian-Swiss-Egyptian Neurodevelopmental Study
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自闭症和脆性 X 综合症的大脑形态与社交智商相关：加拿大、瑞士、埃及神经发育研究的第一份报告
DOI：
10.1177/0883073809341670
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发表时间：
2010
影响因子：
1.9
通讯作者：
Alan C. Evans
中科院分区：
文献类型：
--
作者：
N. Meguid;C. Fahim;U. Yoon;N. Nashaat;A. Ibrahim;A. Mancini;C. Brandner;Alan C. Evans
Fragile X syndrome shares most of the behavioral phenotypic similarities with autism. How are these similarities reflected in brain morphology? A total of 10 children with autism and 7 with fragile X underwent morphological (T1) 1.5-T magnetic resonance imaging (MRI). The authors found no significant difference in total brain volumes, regional volumes, gyrification index, sulcul depth, and cerebral cortical thickness. However, children with autism showed significant decrease in the medial prefrontal bilaterally and the left anterior cingulate cortices. Regression analysis revealed positive correlation between the medial prefrontal cortical thickness and the social IQ. The authors suggest that the difference between the 2 groups in the medial prefrontal and anterior cingulate cortices thickness may entail an altered social cognitive style. Functional MRI studies directly differentiating between social indifference (autism) and social avoidance (fragile X) are needed to further characterize the spectrum of social abnormalities between these 2 groups.
年轻女性中与脆性 X 相关的精神疾病。
影响因子：
8
作者：
Freund,LS;Reiss,AL;Abrams,MT
通讯作者：
Abrams,MT
影响因子：
120.7
作者：
Castellanos, FX;Lee, PP;Rapoport, JL
通讯作者：
Rapoport, JL
DOI：
10.1073/pnas.94.10.5401
发表时间：
1997-05-13
影响因子：
11.1
作者：
Comery, TA;Harris, JB;Greenough, WT
通讯作者：
Greenough, WT