Association study between single nucleotide polymorphisms in promoter region of AVPR1A and Korean autism spectrum disorders
Association study between single nucleotide polymorphisms in promoter region of AVPR1A and Korean autism spectrum disorders
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DOI：
10.1016/j.neulet.2010.05.050
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发表时间：
2010-08-02
影响因子：
2.5
通讯作者：
Kim, Soon Ae
中科院分区：
文献类型：
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作者：
Yang, So Young;Cho, Soo-Churl;Kim, Soon Ae
为探讨精氨酸加压素受体1A基因(AVPR1A)与自闭症谱系障碍(ASD)的关系，采用家族关联试验(FBAT)检测了AVPR1A启动子区域rs7294536、rs3759292和rs10877969三个单核苷酸多态(SNPs)。我们的结果显示孤独症与SNPs有显著的相关性(加性模型：rs7294536，chi(2)=9.328，df=2，P=0.002：rs10877969，chi(2)=11.529，df=2，P
To determine the association between arginine vasopressin receptor 1A gene (AVPR1A)and autism spectrum disorders (ASDs), we examined 3 single nucleotide polymorphisms (SNPs), namely, rs7294536, rs3759292, and rs10877969, in the promoter region of AVPR1A by using a family-based association test (FBAT) in 151 Korean trios. Our results demonstrated a statistically significant association between autism and SNPs (additive model: rs7294536, chi(2)=9.328, df=2, P=0.002: rs10877969, chi(2)=11.529, df=2, P