Interpretation of the international normalised ratio in patients with liver disease
Interpretation of the international normalised ratio in patients with liver disease
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DOI：
10.1016/s0140-6736(02)07282-3
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发表时间：
2002-01-05
期刊：
影响因子：
168.9
通讯作者：
Deitcher, SR
中科院分区：
文献类型：
--
作者：
Deitcher, SR
国际标准化比率（INIR）和具有低国际敏感性指数（ISIs）的凝血酶的广泛接受无意中导致INR应用于抗凝治疗以外的患者。我在接受稳定剂量华法林治疗的肝病患者和对照组中检查了给定INR的因子缺乏程度。在给定的INR下，肝脏患者的因子V和因子VII的缺乏程度，而不是凝血酶原的缺乏程度，高于对照组。使用低isi凝血活素测量的INR可以量化肝病患者的凝血状态，但不应被解释为与使用华法林患者的INR具有相同的含义。
Wide acceptance of the International normalised ratio (INIR) and thromboplastins with low International sensitivity Indices (ISIs) has Inadvertently led to the application of the INR to patients other than those on anticoagulation treatment. I examined the degree of factor deficiency for a given INR In patients with liver disease and controls receiving stable-dose warfarin. The degree of factor V and VII, but not prothrombin, deficiencies for a given INR were greater In liver patients than controls. The INR measured with a low-ISI thromboplastin can quantify the coagulation status of patients with liver disease, but should not be Interpreted as having the same meaning as the INR In patients receiving warfarin.