Multivariate evaluation of doxorubicin surface-enhanced Raman spectra
Multivariate evaluation of doxorubicin surface-enhanced Raman spectra
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DOI：
10.1016/s1386-1425(01)00453-x
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发表时间：
2001-08-01
影响因子：
4.4
通讯作者：
Abrahamsson, K
中科院分区：
文献类型：
--
作者：
Eliasson, C;Lorén, A;Abrahamsson, K
多柔比星在血浆中的表面增强拉曼光谱的多变量评估。在主成分分析（PCA）中，所有光谱特征被建模为三个主成分。数据的主要变化是阿霉素拉曼信号和阿霉素荧光的变化，而由于血浆的变化是次要的。表面增强拉曼散射（Sers）测量结果与测量时机、银胶体等因素无关。所呈现的结果表明，通过一些改进，可以直接定量血浆中的多柔比星。(C)2001 Elsevier Science B.V.保留所有权利。
Multivariate evaluation of surface-enhanced Raman spectra of doxorubicin in plasma was performed. In a principal component analysis (PCA) all spectral features were modelled into three principal components. The major variation of the data was shown to be the variation of doxorubicin Raman signal together with the doxorubicin fluorescence, whereas the variation due to plasma was of minor importance. It was also shown that the surface-enhanced Raman scattering (SERS) measurements were independent on such factors as measurement occasion and silver colloids. The presented results show that with some improvements, quantification of doxorubicin directly in plasma could be possible. (C) 2001 Elsevier Science B.V. All rights reserved.