Lower versus higher haemoglobin threshold for transfusion in septic shock
Lower versus higher haemoglobin threshold for transfusion in septic shock
复制标题
败血性休克输血的血红蛋白阈值较低与较高
DOI：
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发表时间：
2015
影响因子：
2.7
通讯作者：
E. Sisler
中科院分区：
文献类型：
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作者：
E. Sisler
三部分临床问题：患者：重症监护病房（ICU）患有感染性休克和血红蛋白（Hb） 49 g/dl的成年患者。干预：患者被随机分配到低阈值（血红蛋白47克/分升，“限制性”）或高阈值（血红蛋白49克/分升，“自由”）输血策略；为了达到指定的输血阈值，他们被给予了单个交叉匹配的低白细胞红细胞。结果：主要结果是随机分组后90天的死亡率。次要结局包括在第5、14和28天对生命支持的需求（肾脏替代治疗、机械通气、肌力支持）；发生严重不良反应的；90天无生命支持存活天数和90天院外存活天数。
Three part clinical question: Patients:Adult patients in the intensive care unit (ICU) with septic shock and haemoglobin (Hb) 49 g/dl. Intervention: Patients were randomly assigned to either a lower threshold (Hb 47 g/dl, ‘restrictive’) or higher threshold (Hb 49 g/dl, ‘liberal’) transfusion strategy; they were given single cross-matched units of leucodepleted red blood cells to achieve the assigned transfusion threshold. Outcomes: Primary outcome was mortality rate at 90 days post-randomisation. Secondary outcomes included the requirement for life support (renal replacement therapy, mechanical ventilation, inotropic support) at days 5, 14 and 28; the occurrence of serious adverse reactions; number of days alive without life support at 90 days and days alive outside of hospital at 90 days.