Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells
Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells
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DOI：
10.1016/j.bbrc.2006.04.076
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发表时间：
2006-06-23
影响因子：
3.1
通讯作者：
Pecquery, Rene
中科院分区：
文献类型：
--
作者：
Dieudonne, Marie-Noelle;Bussiere, Marianne;Pecquery, Rene
众所周知，肥胖是乳腺癌的危险因素，脂联素（一种主要由白色脂肪细胞分泌的激素）的血液水平与体脂量呈负相关。由于脂联素在某些细胞类型中具有抗增殖作用，我们验证了脂联素可以影响人乳腺癌MCF-7细胞生长的假设。在这里，我们表明MCF-7细胞表达脂联素受体，并通过减少其生长、AMP激酶激活和p42/p44 MAP激酶失活来响应人重组脂联素。此外，我们证明脂联素的抗增殖作用涉及激活细胞凋亡和抑制细胞周期。这些结果表明，脂联素可以在体内作为一个旁分泌/内分泌生长抑制剂对乳腺上皮细胞。此外，脂肪脂联素的产生在肥胖中强烈减少，这项研究可能有助于解释为什么肥胖是乳腺癌发生的危险因素。(c)2006年爱思唯尔公司All rights reserved.
It is well established that obesity is a risk factor for breast cancer and that blood levels of adiponectin, a hormone mainly secreted by white adipocytes, are inversely correlated with the body fat mass. As adiponectin elicits anti-proliferative effects in some cell types, we tested the hypothesis that adiponectin could influence human breast cancer MCF-7 cell growth. Here we show that MCF-7 cells express adiponectin receptors and respond to human recombinant adiponectin by reducing their growth, AMPkinase activation, and p42/p44 MAPkinase inactivation. Further, we demonstrate that the anti-proliferative effect of adiponectin involves activation of cell apoptosis and inhibition of cell cycle. These findings suggest that adiponectin could act in vivo as a paracrine/endocrine growth inhibitor towards mammary epithelial cells. Moreover, adipose adiponectin production being strongly reduced in obesity, this study may help to explain why obesity is a risk factor of developing breast cancers. (c) 2006 Elsevier Inc. All rights reserved.