Direct synthesis of hydroxamates from carboxylic acids using 2-mercaptopyridone-1-oxide-based thiouronium salts
Direct synthesis of hydroxamates from carboxylic acids using 2-mercaptopyridone-1-oxide-based thiouronium salts
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DOI：
10.1016/s0040-4039(01)00923-6
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发表时间：
2001-07-23
影响因子：
1.8
通讯作者：
Nájera, C
中科院分区：
文献类型：
--
作者：
Bailén, MA;Chinchilla, R;Nájera, C
衍生自2-巯基吡啶酮-1-氧化物和四甲基脲（TOTT和HOTT）或N，N ' -二甲基亚丙基脲（TODT和HODT）的四氟硼酸盐和六氟磷酸盐硫脲鎓盐通过与N，O-二甲基羟胺和O-甲基-或O-苄基-羟胺盐酸盐反应，以高产率将羧酸转化为Weinreb酰胺和N-甲氧基或N-苄氧基酰胺。分别在三乙胺或DIEA的存在下。(C)2001 Elsevier Science Lid. All rights reserved.
Tetrafluoroborate and hexafluorophosphate thiouronium salts derived from 2-mercaptopyridone-1-oxide and tetramethylurea (TOTT and HOTT) or N,N ' -dimethylpropyleneurea (TODT and HODT) convert carboxylic acids to Weinreb amides and N-methoxy or N-benzoxyamides in high yields by reaction with N,O-dimethylhydroxylamine and O-methyl- or O-benzyl-hydroxylamine hydroxylamine hydrochlorides. respectively. in the presence of triethylamine or DIEA. (C) 2001 Elsevier Science Lid. All rights reserved.