NERVE GROWTH-FACTOR - STIMULATION OF POLYMORPHONUCLEAR LEUKOCYTE CHEMOTAXIS INVITRO
NERVE GROWTH-FACTOR - STIMULATION OF POLYMORPHONUCLEAR LEUKOCYTE CHEMOTAXIS INVITRO
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DOI：
10.1073/pnas.80.23.7215
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
YOUNG, M
中科院分区：
文献类型：
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作者：
GEE, AP;BOYLE, MDP;YOUNG, M
将小鼠神经生长因子（NGF）局部应用于小鼠的浅表皮肤伤口先前已显示加速伤口收缩的速率。血浆中的NGF在体外对人多形核白细胞也有明显的趋化作用，这种作用所需的NGF浓度与刺激神经节神经突生长的浓度相似。这种性质不是由补体C5a片段的释放引起的，也不需要已知的NGF酶活性。(NGF用DFP灭活的活性相同）。神经生长因子对非神经源性细胞具有生物学效应，这一特性可能在损伤后的早期炎症反应中发挥作用。
Topical application of mouse nerve growth factor (NGF) to superficial skin wounds of mice has previously been shown to accelerate the rate of wound contraction. NGF in the presence of plasma apparently is also chemotactic for human polymorphonuclear leukocytes in vitro, and the concentration of NGF required for this effect is similar to that which stimulates ganglionic neurite outgrowth. This property does not arise from liberation of the C5a fragment of complement, nor does it require the known enzymic activity of NGF. (NGF inactivated with DFP is equally active.) NGF can display biological effects on cells of non-neural origin and function, and this feature might play a role in the early inflammatory response to injury.