Stabilisation of lipid membrane-incorporated porphyrin derivative aqueous solutions and their photodynamic activities
Stabilisation of lipid membrane-incorporated porphyrin derivative aqueous solutions and their photodynamic activities
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DOI：
10.1039/c8pp00350e
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发表时间：
2019-02-01
影响因子：
3.1
通讯作者：
Ikeda, Atsushi
中科院分区：
文献类型：
--
作者：
Nakaya, Toshimi;Horiguchi, Banri;Ikeda, Atsushi
具有三个苯基部分和一个吡啶基或吡啶鎓部分的脂质膜掺入卟啉衍生物（LMIPors）比具有苯基和/或吡啶基部分的LMIPors更稳定。前两种LMIPors在波长超过600 nm的光照射下对癌细胞显示出高的光动力活性，这是最适合于光动力治疗的。光动力活性大于Photofrin，Photofrin是目前临床上用作光敏剂的主要药物。这些结果代表了LMIPors作为光敏剂的优化的重大进展。
Lipid membrane-incorporated porphyrin derivatives (LMIPors) having three phenyl moieties and one pyridyl or pyridinium moiety at the meso-positions were more stable than LMIPors having phenyl and/or pyridyl moieties. The former two LMIPors showed high photodynamic activity toward cancer cells under photoirradiation at wavelengths over 600 nm, which are the most suitable for photodynamic therapy. The photodynamic activities were greater than that of Photofrin, which is currently the main drug employed clinically as a photosensitiser. The results represent significant progress toward the optimisation of LMIPors as photosensitisers.