TISSUE GLUTATHIONE, NUTRITION, AND OXIDATIVE STRESS
TISSUE GLUTATHIONE, NUTRITION, AND OXIDATIVE STRESS
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DOI：
10.1139/y93-111
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发表时间：
1993-09-01
影响因子：
2.1
通讯作者：
TAYLOR, CG
中科院分区：
文献类型：
--
作者：
BRAY, TM;TAYLOR, CG
谷胱甘肽是一种含半胱氨酸的三肽，是哺乳动物细胞中含量最多的非蛋白硫醇。谷胱甘肽在解毒外源化合物和抗氧化活性氧和自由基中起重要作用。由于其在多种组织中具有多种功能，并参与许多疾病和营养不良，因此清楚地了解组织谷胱甘肽、营养和氧化应激之间的相互关系具有临床意义。本综述的重点是讨论饮食和营养状况对组织谷胱甘肽浓度的调节，并将这些信息应用于那些与组织谷胱甘肽减少和氧化应激增加有关的疾病和营养不良。讨论了在营养不良患者治疗前快速恢复抗氧化和免疫防御系统谷胱甘肽的潜在策略。
Glutathione, a cysteine-containing tripeptide, is the most abundant nonprotein thiol in mammalian cells. Glutathione plays an important role in the detoxification of xenobiotic compounds and in the antioxidation of reactive oxygen species and free radicals. Because of its multiple functions in various tissues and its involvement in many diseases and malnutrition, a clear understanding of the interrelationships among tissue glutathione, nutrition, and oxidative stress is clinically relevant. The focus of this review is to discuss the regulation of tissue glutathione concentration by diet and nutritional status, and to apply this information to those diseases and malnutrition in which decreased tissue glutathione and increased oxidative stress are implicated. A potential strategy to rapidly restore glutathione for both antioxidant and immune defense systems before therapeutic treatment in malnourished patients is discussed.