Selective release of gastric inhibitory polypeptide by intraduodenal amino acid perfusion in man.
Selective release of gastric inhibitory polypeptide by intraduodenal amino acid perfusion in man.
复制标题
通过人十二指肠内氨基酸灌注选择性释放胃抑制多肽。
DOI：
10.1016/0016-5085(78)90703-5
复制
发表时间：
1978
期刊：
影响因子：
29.4
通讯作者：
J. Fromkes
中科院分区：
文献类型：
--
作者：
F. Thomas;D. Sinar;E. Mazzaferri;S. Cataland;H. Mekhjian;J. Caldwell;J. Fromkes
十二指肠内氨基酸可以刺激胃抑制多肽和缩胆囊素的释放。为了有选择地分离和定量胃抑制多肽的分泌，12名正常受试者接受了十二指肠内灌流，分别是含有蛋氨酸、苯丙氨酸、色氨酸和缬氨酸的混合氨基酸溶液(158 MM)或含有精氨酸、组氨酸、异亮氨酸、亮氨酸、赖氨酸和苏氨酸的混合氨基酸溶液(灌流液2)。灌流液2组的血清胃抑制多肽和胰岛素浓度显著升高(P<；0.001)。而氨基酸灌流液1号灌流后，血清胃抑素浓度仅略有升高，胰岛素分泌仅略有增加。接受灌流液1的组的平均胰酶和胆红素的产量几乎是接受其他氨基酸混合物的组的3倍。本研究扩大了十二指肠内氨基酸混合物在刺激胃抑制多肽和胰岛素分泌中的重要性，并将胃抑制多肽的释放与刺激胰酶分泌的激素(如胆囊收缩素)的释放进行了定量分离。
Intraduodenal amino acids are known to stimulate the release of gastric inhibitory polypeptide and cholecystokinin. In order to separate and quantitate gastric inhibitory polypeptide secretion selectively, 12 normal subjects received an intraduodenal perfusion of a mixed amino acid solution (158 mM) containing either methionine, phenylalanine, tryptophan, and valine (perfusate 1), or an amino acid solution containing arginine, histidine, isoleucine, leucine, lysine, and threonine (perfusate 2). Serum concentrations of gastric inhibitory polypeptide and insulin were significantly greater in the group receiving perfusate 2 (P< 0.001). In contrast, after administration of amino acid perfusate 1, there was only a slight increase in serum gastric inhibitory polypeptide concentration and insulin secretion increased only slightly. Mean trypsin and bilirubin outputs in the group receiving perfusate 1 were nearly 3 times greater than the outputs of the group receiving the other amino acid mixture. This study expands the importance of intraduodenal amino acid mixtures in stimulating secretion of gastric inhibitory polypeptide and insulin and quantitatively separates gastric inhibitory polypeptide release from release of hormones that stimulate pancreatic enzyme secretion, such as cholecystokinin.