Pharmacogenomics and Pharmacoproteomics Studies ofPhosphodiesterase-5 (PDE5) Inhibitors and Paclitaxel Albumin-StabilizedNanoparticles as Sandwiched Anti-Cancer Nano Drugs between TwoDNA/RNA Molecules of Human Cancer Cells
Pharmacogenomics and Pharmacoproteomics Studies ofPhosphodiesterase-5 (PDE5) Inhibitors and Paclitaxel Albumin-StabilizedNanoparticles as Sandwiched Anti-Cancer Nano Drugs between TwoDNA/RNA Molecules of Human Cancer Cells
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DOI：
10.4172/2153-0645.1000e153
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
A. Heidari
中科院分区：
文献类型：
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作者：
A. Heidari
治疗是抗癌纳米药物如磷酸二酯酶-5(PDE5)抑制剂和紫杉醇蛋白不稳定纳米粒的医学、药理学、药学、生理学、临床、生物学、医学和医学、生物化学、药物基因组学和药物蛋白质组学研究的重要目标之一。目前制备抗癌纳米药物的方法和技术，特别是磷酸二酯酶-5(PDE5)抑制剂和紫杉醇蛋白不稳定纳米粒，有望在未来几十年达到其极限。最小的抗癌纳米药物大约有5纳米宽，数亿种药物可能集成在一个分子上。在这个尺寸以下，控制掺杂变得越来越困难。治疗的下一个重要步骤可能是将抗癌纳米药物，如磷酸二酯酶-5(PDE5)抑制剂和紫杉醇蛋白不稳定纳米粒降低到人类癌细胞DNA/RNA分子的规模(图1和图2)。这个涉及医学、药理学、药学、生理学、临床、生物、医学和医学、生物化学、药物基因组学和药物蛋白质组学的新领域被称为药物治疗。最近，几位研究人员测量了单个或小群生物有机分子的电子传递，如连接到镉或钌等金属的人类癌细胞的DNA/RNA[1-29]。
One of the most important goals in the medicine, pharmacology, pharmaceutical, physiological, clinical, biological, medical and medicinal sciences, biochemistry, pharmacogenomics and pharmacoproteomics of anti-cancer Nano drugs such as phosphodiesterase-5 (PDE5) inhibitors and paclitaxel albuminstabilized nanoparticles is the treatment. The present methods and techniques of Nano-structuring anti-cancer Nano drugs, especially phosphodiesterase-5 (PDE5) inhibitors and paclitaxel albuminstabilized nanoparticles, are expected to reach their limitations in the next decades. The smallest anti-cancer Nano drugs are of about five nanometers wide and hundreds of millions of them maybe integrated on a single molecule. Below this size the controlled doping becomes more and more difficult. The next important step in the treatment might be done by reducing the anti-cancer Nano drugs such as phosphodiesterase-5 (PDE5) inhibitors and paclitaxel albuminstabilized nanoparticles to the scale of DNA/RNA molecules of human cancer cells (Figures 1 and 2). This new filed of medicine, pharmacology, pharmaceutical, physiological, clinical, biological, medical and medicinal sciences, biochemistry, pharmacogenomics and pharmacoproteomics is called pharmachemotherapy. Recently, several researchers have measured electron transport in single or small groups of bioorganic molecules such as DNA/RNA of human cancer cells connected to metal such as Cadmium or Ruthenium (Figure 3) [1-29].