Organocatalytic Domino Entry to an Octahydroacridine Scaffold Bearing Three Contiguous Stereocenters
Organocatalytic Domino Entry to an Octahydroacridine Scaffold Bearing Three Contiguous Stereocenters
复制标题
有机催化多米诺骨牌进入带有三个连续立构中心的八氢吖啶支架
DOI：
10.1021/acs.joc.8b01875
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发表时间：
2018-10-05
影响因子：
3.6
通讯作者：
Yang, Hua
中科院分区：
文献类型：
--
作者：
Li, Shuang;Wang, Jing;Yang, Hua
通过环己酮和2- n -取代苯甲醛之间的有机催化多米诺骨牌序列，开发了一种方便和对映选择性的功能化八氢吖啶支架。高水平的产率（高达99%）和对端选择性（高达99:1 er）在这种发展的有机催化转化中很容易实现，这在构建复杂的多环系统以进一步进行药理学研究方面具有广阔的应用前景。
A facile and enantioselective access to a functionalized octahydroacridine scaffold was developed via an organocatalytic domino sequence between cyclohexenone and 2-N-substituted benzaldehyde. High levels of yields (up to 99%) and enantioselectivities (up to 99:1 er) were readily achieved in this developed organocatalytic transformation, which holds promising applications in the construction of complex multicyclic systems for further pharmacological studies.