Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy.
Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy.
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DOI：
10.2741/3505
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Ling Zheng;T. Kern
中科院分区：
文献类型：
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作者：
Ling Zheng;T. Kern
糖尿病视网膜病变是工业化世界中导致失明和视力残疾的主要原因。糖尿病视网膜病变的发生机制仍是一个悬而未决的问题。导致氧化和亚硝化应激的改变，包括一氧化氮(NO)和超氧化物生成增加，不同亚型的一氧化氮合酶(NOS)，硝化和多聚(ADP-核糖)蛋白的过度表达，以及抗氧化酶的下调，都参与了这种眼病的发病机制。本文综述了这些成分在糖尿病视网膜病变发生发展中的可能作用，并强调了它们作为抑制或延缓糖尿病视网膜病变发展的治疗靶点的价值。
Diabetic retinopathy is the leading cause of blindness and visual disability in the industrialized world. The mechanisms of how diabetic retinopathy develops are still an open question. Alterations contributing to oxidative and nitrosative stress, including elevated nitric oxide (NO) and superoxide production, overexpression of different isoforms of nitric oxide synthase (NOS), nitrated and poly(ADP-ribosy)lated proteins, and downregulation of antioxidative enzymes have been implicated in the pathogenesis of this ocular disease. The possible roles of these components in the development of diabetic retinopathy are reviewed here, and their values as therapeutic targets for inhibiting or delaying the development of diabetic retinopathy are highlighted.