ION TRANSPORT BY HEART-MITOCHONDRIA .25. ACTIVATION OF ENERGY-LINKED K+ UPTAKE BY NONIONIC DETERGENTS
ION TRANSPORT BY HEART-MITOCHONDRIA .25. ACTIVATION OF ENERGY-LINKED K+ UPTAKE BY NONIONIC DETERGENTS
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DOI：
10.1016/0003-9861(72)90270-6
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发表时间：
1972-01-01
影响因子：
3.9
通讯作者：
MEROLA, AJ
中科院分区：
文献类型：
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作者：
BRIERLEY, GP;SCOTT, KM;MEROLA, AJ
Triton X-100和其他几种非离子去污剂可显著激活离体心脏线粒体对K+盐的能量依赖性摄取。洗涤剂介导的反应非常类似于在低浓度的离子载体缬氨霉素存在下观察到的反应。Triton增加能量相关的K+吸收的效率，诱导K+的被动渗透性，并以类似于缬氨霉素的方式影响呼吸、磷酸化、O2脉冲和ATP酶活性。阳离子平衡萃取到有机溶剂中的研究表明，具有聚（乙烯氧基）乙醇结构的洗涤剂可以起到离子载体的作用，其性质大致类似于环状聚醚。具有作为离子载体的能力的洗涤剂的效果与其他类别的表面活性试剂的效果进行比较。
The energy-dependent uptake of K+salts by isolated heart mitochondria is markedly activated by Triton X-100 and several other nonionic detergents. The detergent-mediated reaction closely resembles that seen in the presence of low concentrations of the ionophore valinomycin. Triton increases the efficiency of energylinked K+uptake, induces passive permeability to K+, and affects respiration, phosphorylation, O2pulses, and ATPase activity in a manner similar to valinomycin. Studies of equilibrium extraction of cations into organic solvents indicate that detergents with the poly(ethyleneoxy) ethanol structure can function as ionophores with properties roughly analogous to the cyclic polyethers. The effects of detergents with the ability to act as ionophores are compared with those of other classes of surface-active reagents.