The nucleosome remodeling factor.
The nucleosome remodeling factor.
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DOI：
10.1016/j.febslet.2011.09.003
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发表时间：
2011-10-20
期刊：
影响因子：
3.5
通讯作者：
Landry JW
中科院分区：
文献类型：
--
作者：
Alkhatib SG;Landry JW
染色质重塑机制的一个重要组成部分是核小体重塑因子（Nucleosome Remodeling Factor，NF），它是染色质重塑复合物ISWI家族的创始成员。在脊椎动物和无脊椎动物中，BMPF在染色质生物学中具有许多重要功能，包括调节转录，建立边界元件和促进更高级的染色质结构。由于BNF对染色质生物学的许多方面都是必不可少的，因此需要了解其功能才能完全理解基因组是如何调节的。本文将总结目前已知的其生物学功能，在最突出的模式生物，作为核小体重塑酶的生化功能，以及其可能与人类癌症的保护。
An essential component of the chromatin remodeling machinery is NURF (Nucleosome Remodeling Factor), the founding member of the ISWI family of chromatin remodeling complexes. In vertebrates and invertebrates alike, NURF has many important functions in chromatin biology including regulating transcription, establishing boundary elements, and promoting higher order chromatin structure. Since NURF is essential to many aspects of chromatin biology, knowledge of its function is required to fully understand how the genome is regulated. This review will summarize what is currently known of its biological functions, conservation in the most prominent model organisms, biochemical functions as a nucleosome remodeling enzyme, and its possible relevance to human cancer.