Plasma tissue factor antigen in localized prostate cancer: Distribution, clinical significance and correlation with haemostatic activation markers
Plasma tissue factor antigen in localized prostate cancer: Distribution, clinical significance and correlation with haemostatic activation markers
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DOI：
10.1160/th06-09-0523
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发表时间：
2007-03-01
影响因子：
6.7
通讯作者：
Francis, John L.
中科院分区：
文献类型：
--
作者：
Langer, Florian;Chun, Felix Kyoung-Hwan;Francis, John L.
组织因子（TF）参与癌症的生长和转移，并且在大多数晚期恶性肿瘤（包括前列腺癌（PC））患者中发现止血异常。由于抗止血剂越来越多地筛选其延长肿瘤患者生存期的潜力，在选定的癌症亚型和临床阶段的止血标志物的详细表征是必要的。在这项研究中，我们测量了一个大型队列的局部PC患者的术前血浆TF抗原，并将其水平与凝血和血小板活化标志物、前列腺特异性抗原（PSA）和组织病理学结果相关联，以探讨其作为该肿瘤实体预后标志物的潜力。在140名患者中，19%和23%的血浆TF抗原水平分别< 40 pg/ml（低TF）和> 200 pg/ml（高TF），这远高于42名健康男性对照。患者还具有低级别的全身凝血激活，如升高的D-受体、F1+2和PAP血浆水平所证明的。此外，与sP-选择素和sCD 40 L抗原相似，血浆中血小板衍生微粒的流式细胞术分析显示，与低TF患者和对照组相比，高TF患者血小板衍生微粒的数量显著增加。尽管D-受体升高与较大和分化程度较低的肿瘤相关，但术前血浆TF抗原水平（中位数[IQR]）在PC患者中（161 pg/ml [100-236]）高于未复发PC患者（105 pg/ml [52-182]），如门诊随访期间血清PSA> 0.1 ng/ml所示。在局限性PC患者中，术前血浆TF抗原水平与体内血小板活化相关，并可能表明疾病复发的风险增加。
Tissue factor (TF) is involved in cancer growth and metastasis, and haemostatic abnormalities are found in most patients with advanced malignancies, including prostate cancer (PC). Because anti-haemostatic agents are increasingly screened for their potential to prolong survival in tumor patients, a detailed characterization of haemostatic markers in selected cancer subtypes and clinical stages is warranted. In this study, we measured Preoperative plasma TF antigen in a large cohort of patients with localized PC and correlated its levels with markers of coagulation and platelet activation, prostate-specific antigen (PSA), and histopathological findings to explore its potential as a prognostic marker in this tumor entity. Out of 140 patients, 19% and 23% had plasma TF antigen levels of < 40 pg/ml (low-TF) and > 200 pg/ml (high-TF), respectively, which was substantially higher than in 42 healthy male controls. Patients also had low-grade systemic coagulation activation as evidenced by elevated D-climer, F1+2, and PAP plasma levels. Furthermore, similar to sP-selectin and sCD40L antigen, flow cytometric analysis of platelet-derived microparticles in plasma revealed significantly increased numbers in high-TF as compared to low-TF patients and controls. Whereas elevated D-climer was associated with larger and less differentiated tumors, preoperative plasma TF antigen levels (median [IQR]) were higher in patients with (161 pg/ml [100-236]) than in those without recurrent PC (105 pg/ml [52-182]), as indicated by a serum PSA of > 0.1 ng/ml during ambulatory follow-up. In patients with localized PC, preoperative plasma TF antigen levels correlate with platelet activation in vivo and may indicate an increased risk for recurrent disease.