Role of sex steroids, intrahepatic fat and liver enzymes in the association between SHBG and metabolic features
Role of sex steroids, intrahepatic fat and liver enzymes in the association between SHBG and metabolic features
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DOI：
10.1111/cen.12089
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发表时间：
2013-10-01
影响因子：
3.2
通讯作者：
Ducluzeau, Pierre-Henri
中科院分区：
文献类型：
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作者：
Bonnet, Fabrice;Cephise, Fritz-Line Velayoudom;Ducluzeau, Pierre-Henri
背景SHBG和肝酶水平都与2型糖尿病的风险有关。然而，SHBG与肝酶和肝内脂肪含量之间的关系仍然知之甚少。目的研究SHBG是否与葡萄糖和脂质水平相关，以及这种关联是否取决于脂肪肝含量，肝酶或性激素浓度。设计和患者我们研究了233名代谢异常的男性，测量血浆SHBG，总睾酮，17-雌二醇，葡萄糖，脂联素，肝酶和肝细胞因子。其中108例患者通过磁共振成像测量肝内脂肪和内脏脂肪含量。结果校正年龄后，SHBG浓度与空腹血糖呈负相关（β（标准化）=-0.21，P = 0.0007），HbA 1c（β（标准化）=-0.27，P < 0.0001），甘油三酯（β（标准化）=-0.19，P = 0.003），与高密度脂蛋白胆固醇呈正相关（β（标准化）= 0.14，P = 0.03）。这些相关性持续调整后，无论是总睾酮或17 β-雌二醇水平。SHBG与胎球蛋白A或FGF 21浓度无关。SHBG与HbA 1c和血脂水平的负相关性在调整肝脏标志物后没有改变，但在调整肝脏脂肪含量后不再显着。结论SHBG与空腹血糖、HbA 1c和血脂水平在代谢异常的男性中的显着相关性与性激素或肝功能标志物无关，但依赖于肝内脂肪。这表明，肝内脂肪，而不是肝功能标志物的改变，可能参与SHBG和糖脂代谢之间的关联。
Background SHBG and liver enzymes levels are both associated with the risk of type 2 diabetes. However, the relationship between SHBG with liver enzymes and intrahepatic fat content remain poorly understood.Objective To investigate whether SHBG is correlated with glucose and lipids levels and whether this association depends on fatty liver content, liver enzymes or sex hormone concentrations.Design and Patients We studied 233 dysmetabolic men with measures of plasma SHBG, total testosterone, 17-oestradiol, glucose, adiponectin, liver enzymes and hepatokines. Intrahepatic liver fat and visceral fat contents were measured by magnetic resonance imaging in 108 of these individuals.Results After adjustment for age, SHBG concentration was inversely correlated with fasting glucose (beta(standardized) = -0.21, P = 0.0007), HbA1c (beta(standardized) = -0.27, P < 0.0001), triglycerides (beta(standardized) = -0.19, P = 0.003) and positively correlated with HDL-Cholesterol (beta(standardized) = 0.14, P = 0.03). These correlations persisted after adjustment for either total testosterone or 17 beta-oestradiol levels. SHBG was not related to either fetuin A or FGF 21 concentrations. The inverse association of SHBG with HbA1c and glycaemia was not altered after adjusting for liver markers but was no longer significant after adjustment for hepatic fat content.Conclusion The significant association between SHBG and fasting glycaemia, HbA1c and lipid levels in dysmetabolic men was not related to either sex hormones or markers of liver function, but was dependent on intrahepatic fat. This suggests that intrahepatic fat, but not alterations in liver function markers, may be involved in the association between SHBG and glucose and lipid metabolism.