High-dose nicotine patch therapy for smokers with a history of alcohol dependence: 36-week outcomes
High-dose nicotine patch therapy for smokers with a history of alcohol dependence: 36-week outcomes
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DOI：
10.1016/j.jsat.2006.01.001
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发表时间：
2006-04-01
影响因子：
3.9
通讯作者：
Monti, PM
中科院分区：
文献类型：
--
作者：
Kalman, D;Kahler, CW;Monti, PM
本研究报告了高剂量尼古丁贴片（NP）治疗有酒精依赖史的重度吸烟者的疗效调查结果。130名参与者被随机分配到42或21毫克的透皮尼古丁组。在第4、12、24和36周进行随访评估。剂量条件之间的差异是不显着的，虽然，出乎意料的是，结果有利于参与者在21毫克NP条件。第36周随访时，21 mg和42 mg NP条件下的尼古丁戒断率分别为16.9%和9.2%。贴片条件与尼古丁依赖的严重程度无相互作用。然而，随访时尼古丁戒断与更长时间的酒精戒断有关。没有证据表明更好的结果作为基线可替宁被NP替代的百分比的函数。未来的研究应该主要集中在调查如何提高吸烟者在酒精早期恢复的戒烟率。(c)2006年爱思唯尔公司All rights reserved.
This study reports findings from an investigation of the efficacy of high-dose nicotine patch (NP) therapy for heavy smokers with a history of alcohol dependence. One hundred thirty participants were randomly assigned to 42 or 21 mg of transdermal nicotine. Follow-up assessments were conducted at 4, 12, 24, and 36 weeks. Differences between dose conditions were nonsignificant, although, unexpectedly, outcomes favored participants in the 21-mg NP condition. Nicotine abstinence rates in the 21- and 42-mg NP conditions on Week 36 follow-up were 16.9% and 9.2%, respectively. Patch condition did not interact with severity of nicotine dependence. However, nicotine abstinence at follow-up was related to a longer length of alcohol abstinence. No evidence was found for better outcomes as a function of the percentage of baseline cotinine replaced by NPs. Future research should focus primarily on investigating ways to improve smoking quit rates for smokers in early alcohol recovery. (c) 2006 Elsevier Inc. All rights reserved.