DETERMINATION OF KT/V AND PROTEIN CATABOLIC RATE USING PREDIALYSIS AND POSTDIALYSIS BLOOD UREA NITROGEN CONCENTRATIONS
DETERMINATION OF KT/V AND PROTEIN CATABOLIC RATE USING PREDIALYSIS AND POSTDIALYSIS BLOOD UREA NITROGEN CONCENTRATIONS
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DOI：
10.1159/000187980
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发表时间：
1994-07-01
期刊：
影响因子：
2.5
通讯作者：
MAEDA, K
中科院分区：
文献类型：
--
作者：
SHINZATO, T;NAKAI, S;MAEDA, K
我们开发了一种新的尿素动力学方法，用于同时测定Kt/V和蛋白质分解率（PCR），仅从血液尿素氮（BUN）浓度之前和之后的单次透析。使用这种方法，即使使用具有低中央处理能力的手持计算机，参数也在1.5 s内计算。假设1周内3次透析期间清除的尿素总量等于1周期间（T-w）产生的尿素量（G（w））：[图形]此处，G为产生速率，K为透析器尿素清除率，T为透析时间，C-1、C-2和C-3为相应透析期间的BUN。如果将该方程和表示单次透析过程中尿素动力学的方程一起求解，我们就得到了Kt/V和G的解。使用体重变化校正由此获得的Kt/V和G。校正的Kt/V与经典方法计算的参数具有良好的对应性，并且由本方法确定的G得出的周中PCR相当于经典方法确定的1周平均PCR。
We developed a new urea kinetic method for simultaneous determination of the Kt/V and protein catabolic rate (PCR) only from blood urea nitrogen (BUN) concentrations before and after a single dialysis session. Using this method, the parameters were calculated within 1.5 s even when a hand-held computer with a low central processing capacity is used. The total amount of urea eliminated during three dialysis sessions in 1 week is assumed to be equal to urea volume (G(w)) generated over a 1-week period (T-w):[GRAPHICS]Here, G is the generation rate, K is the dialyzer urea clearance, T is the dialysis time and C-1, C-2 and C-3 are BUN during the respective dialysis session. If this equation and the equation expressing the urea kinetics during a single dialysis session are solved together, we have a solution for Kt/V and G. The thus-obtained Kt/V and G are corrected using the change in body weight. The corrected Kt/V showed a good correspondence with the parameter calculated with the classical method, and the midweek PCR derived from G determined by the present method being equivalent to the PCR averaged for a 1-week period determined by the classical methods.