INTERACTIONS OF SYNTHETIC-POLYMERS WITH CELL-MEMBRANES AND MODEL MEMBRANE SYSTEMS .5. PH-DEPENDENT COMPLEXATION OF POLY(ACRYLIC ACID) DERIVATIVES WITH PHOSPHOLIPID VESICLE MEMBRANES
INTERACTIONS OF SYNTHETIC-POLYMERS WITH CELL-MEMBRANES AND MODEL MEMBRANE SYSTEMS .5. PH-DEPENDENT COMPLEXATION OF POLY(ACRYLIC ACID) DERIVATIVES WITH PHOSPHOLIPID VESICLE MEMBRANES
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DOI：
10.1021/ma00139a009
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发表时间：
1984-01-01
期刊：
影响因子：
5.5
通讯作者：
TIRRELL, DA
中科院分区：
文献类型：
--
作者：
SEKI, K;TIRRELL, DA
Poly (acrylic acid), poly (methacrylic acid), and poly (a-ethylacrylic acid) can be used to modify, in a pH-dependent manner, the properties of phospholipid vesicle membranes. Polymer-lipid complexation causes a decrease in theapparent cooperativity of the lipid melting transition. The “critical pH” forcomplexation may be controlled through variation of the chemical structureand the tacticity of the poly (carboxylic acid). It is suggested that an important driving force for complexation is provided by the formation of hydrogen bonds between un-ionized carboxyl groups of the polymer and the phosphodiester functionsof the lipid surface.
