Reciprocal association between depression and peptic ulcers: Two longitudinal follow-up studies using a national sample cohort
Reciprocal association between depression and peptic ulcers: Two longitudinal follow-up studies using a national sample cohort
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DOI：
10.1038/s41598-020-58783-0
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发表时间：
2020-02-04
影响因子：
4.6
通讯作者：
Choi, Hyo Geun
中科院分区：
文献类型：
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作者：
Kim, So Young;Min, Chanyang;Choi, Hyo Geun
本研究旨在探讨抑郁症与消化性溃疡的双向关系。该研究包括2002年至2013年韩国国民健康保险服务-国家样本队列的≥ 20岁参与者。在研究I中，30，306名抑郁症患者与121，224名对照I参与者1：4匹配。在研究II中，127，590名消化性溃疡患者与127，590名对照II参与者1：1匹配。分层Cox比例风险模型用于分析抑郁症与消化性溃疡（研究I）和消化性溃疡与抑郁症（研究II）的风险比（HR）。抑郁症患者中有8.9%（2703/30306）和对照组中有7.3%（8896/121224）的患者患有消化性溃疡（P
This study was aimed to explore the bidirectional association between depression and peptic ulcers. The >= 20-year-old participants of the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013 were included in the study. In study I, 30,306 depression patients were 1:4 matched with 121,224 control I participants. In study II, 127,590 peptic ulcer patients were 1:1 matched with 127,590 control II participants. The stratified Cox-proportional hazards models were used to analyse the hazard ratio (HR) of depression for peptic ulcers (study I) and of peptic ulcers for depression (study II). A total of 8.9% (2,703/ 30,306) of depression patients and 7.3% (8,896/ 121,224) of patients in the control I group had peptic ulcers (P