miR-17-92 cluster: ups and downs in cancer and aging.
miR-17-92 cluster: ups and downs in cancer and aging.
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DOI：
10.1007/s10522-010-9272-9
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发表时间：
2010-08
期刊：
影响因子：
4.5
通讯作者：
Grillari-Voglauer, Regina
中科院分区：
文献类型：
--
作者：
Grillari, Johannes;Hackl, Matthias;Grillari-Voglauer, Regina
miR-17-92簇编码6个单一成熟的miRNAs，几年前被鉴定为包含第一个致癌miRNAs。现在，这6种miRNAs中的一种，miR-19已被确定为负责这种致癌活性的关键。这反过来又降低了PTEN水平，从而激活了AKT/mTOR通路，该通路也显著参与了生物体寿命的调节。相比之下，发现miR-19和miR-17-92簇的其他成员在几种人类复制和生物衰老模型中普遍下调。综上所述，这些发现表明miR-19和miR-17-92簇的其他成员可能是衰老和癌症之间的重要调节因子。因此，我们在这里简要地总结了这个集群是如何转录调控的，到目前为止已经确认了哪些靶mRNA，以及这可能与生物寿命的调节有关。
The miR-17–92 cluster encoding 6 single mature miRNAs was identified a couple of years ago to contain the first oncogenic miRNAs. Now, one of these 6 miRNAs, miR-19 has been identified as the key responsible for this oncogenic activity. This in turn reduces PTEN levels and in consequence activates the AKT/mTOR pathway that is also prominently involved in modulation of organismal life spans. In contrast, miR-19 and other members of the miR-17–92 cluster are found to be commonly downregulated in several human replicative and organismal aging models. Taken together, these findings suggest that miR-19 and the other members of the miR-17–92 cluster might be important regulators on the cross-roads between aging and cancer. Therefore, we here briefly summarize how this cluster is transcriptionally regulated, which target mRNAs have been confirmed so far and how this might be linked to modulation of organismal life-spans.
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