Persistent paradox of natural history of human T lymphotropic virus type I: Parallel analyses of Japanese and Jamaican carriers
Persistent paradox of natural history of human T lymphotropic virus type I: Parallel analyses of Japanese and Jamaican carriers
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DOI：
10.1086/424598
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发表时间：
2004-11-01
影响因子：
6.4
通讯作者：
Mueller, NE
中科院分区：
文献类型：
--
作者：
Hisada, M;Stuver, SO;Mueller, NE
人类嗜T淋巴细胞病毒I型（HTLV-I）是日本南部和加勒比地区的地方病，但HTLV-I相关疾病的发病率因地理区域而异。我们比较了来自日本和牙买加的51对年龄和性别匹配的HTLV-I携带者之间的疾病发病机制的标志物。牙买加受试者的平均抗体滴度（P = 0.03）和抗Tax抗体检测（P = 0.002）高于日本受试者，但两组之间的前病毒载量相似（P = 0.26）。牙买加受试者中抗体滴度和前病毒载量之间的相关性比日本受试者中的相关性更显著（）。这些发现强调了2个人群中对HTLV-I感染的宿主免疫应答的差异。
Human T lymphotropic virus type I (HTLV-I) is endemic in southern Japan and the Caribbean, but the incidence of HTLV-I-associated diseases varies across geographic areas. We compared markers of disease pathogenesis among 51 age- and sex-matched HTLV-I carrier pairs from Japan and Jamaica. The mean antibody titer (P = .03) and detection of anti-Tax antibody (P = .002) were higher in Jamaican subjects than in Japanese subjects, but provirus load was similar between the 2 groups (P = .26). The correlation between antibody titer and provirus load was more prominent among Jamaican subjects than among Japanese subjects (). These findings underscore the differences in host immune response to HTLV-I infection in 2 populations.