Coinfection of multiple strains of Epstein-Barr virus in immunocompetent normal individuals: reassessment of the viral carrier state
Coinfection of multiple strains of Epstein-Barr virus in immunocompetent normal individuals: reassessment of the viral carrier state
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DOI：
10.1182/blood.v95.7.2443.007k18_2443_2445
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发表时间：
2000-04-01
期刊：
影响因子：
20.3
通讯作者：
Tao, Q
中科院分区：
文献类型：
--
作者：
Srivastava, G;Wong, KY;Tao, Q
这项研究重新评估了在具有免疫能力的正常携带者中，EB病毒(EBV)多样性和混合感染相对于单一病毒株的优势的出现。对同一个体的外周血单核细胞、多种淋巴组织和上皮组织进行了EBV基因组多个不同多态位点的聚合酶链式反应分析。15名死于与EBV感染无关的原因的人的尸检样本为正常病毒携带者。出乎意料的是，在单个病毒携带者中，同一类型(通常是1型)的多个不同EBV毒株的混合感染，以及较少出现的1型和2型EBV的混合感染，被发现非常高。这些数据表明，与多种EBV毒株混合感染在正常携带者中比以前认识的要普遍得多，这反过来又对EBV的持久性、宿主与病毒的相互作用和致病机制有直接影响。(血。2000；95：2443-2445)(C)2000由美国血液病学会提供。
This study reassesses the occurrence of Epstein-Barr virus (EBV) diversity and coinfection versus dominance of a single viral strain within immunocompetent normal carriers. Polymerase chain reaction analysis of several different polymorphic loci of the EBV genome was performed on collections of peripheral blood mononuclear cells and multiple lymphoid and epithelial tissues of the same individuals. Autopsy specimens from 15 individuals who died of causes unrelated to EBV infection served as normal viral carriers. Unexpectedly, coinfection of multiple distinct strains of EBV of the same type (usually type 1) and less frequently of both types 1 and 2 was found to be very high within individual viral carriers. These data indicate that coinfection with multiple EBV strains is much more prevalent in normal carriers than previously appreciated, which in turn has direct implications on EBV persistence, host-viral interaction and pathogenesis. (Blood. 2000;95:2443-2445) (C) 2000 by The American Society of Hematology.